炎症因子、T淋巴细胞亚群水平与费城染色体阴性骨髓增殖性肿瘤患者预后的关系  

Relationship between inflammatory cytokine,T lymphocyte subset levels and prognosis of patients with Philadelphia chromosom-negative myeloproliferative neoplasm

作　　者：王子峰 李秀琴 张娟 WANG Zifeng;LI Xiuqin;ZHANG Juan(Department of Hematology,the North Campus of Shangrao People’s Hospital,Shangrao 334000,Jiangxi,China)

机构地区：[1]上饶市人民医院城北院区血液内科,江西上饶3340000

出　　处：《癌症进展》2024年第19期2186-2189,共4页Oncology Progress

基　　金：江西省卫生健康委科技计划项目(202212735)。

摘　　要：目的探讨炎症因子、T淋巴细胞亚群水平与费城染色体(Ph)阴性骨髓增殖性肿瘤(MPN)患者预后的关系。方法选取50例Ph阴性MPN患者,均采取口服羟基脲片、皮下注射α干扰素治疗。随访6个月,根据预后情况分为预后良好组(n=23)和预后不良组(n=27)。比较两组患者的炎症因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))水平。采用Spearman相关分析法分析炎症因子、T淋巴细胞亚群水平与Ph阴性MPN患者预后的相关性。结果预后不良组患者的IL-6、IL-8、TNF-α水平均高于预后良好组,差异均有统计学意义(P﹤0.05)。预后不良组患者的CD3^(+)、CD4^(+)水平均明显低于预后良好组,CD8^(+)水平明显高于预后良好组,差异均有统计学意义(P﹤0.01)。IL-6、IL-8、TNF-α、CD8^(+)水平与Ph阴性MPN患者预后不良均呈正相关(P﹤0.05)。CD3^(+)、CD4^(+)水平与Ph阴性MPN患者预后不良均呈负相关(P﹤0.01)。结论炎症因子、T淋巴细胞亚群水平与Ph阴性MPN患者的预后密切相关。Objective To explore the relationship between inflammatory cytokine,T lymphocyte subset levels and prognosis of patients with Philadelphia chromosom(Ph)-negative myeloproliferative neoplasm(MPN).Method A total of 50 Ph-negative MPN patients were selected,and all patients were treated with oral hydroxyurea tablets and subcutaneous injection of alpha interferon.Followed up for 6 months,the patients were divided into good prognosis group(n=23)and poor prognosis group(n=27)according to prognosis.The levels of inflammatory factors[interleukin-6(IL-6),interleukin8(IL-8),tumor necrosis factor-α(TNF-α)]and T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+))were compared between the two groups.Spearman correlation analysis was conducted to analyze the correlation between inflammatory factor,T lymphocyte subset levels and prognosis of Ph-negative MPN patients.Result The levels of IL-6,IL-8 and TNF-αin the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant(P<0.05).The levels of CD3^(+)and CD4^(+)in the poor prognosis group were significantly lower than those in the good prog-nosis group,and the level of CD8^(+)was significantly higher than that in the good prognosis group,and the differences were statistically significant(P<0.01).The levels of IL-6,IL-8,TNF-αand CD8^(+)were positively correlated with poor prognosis of Ph-negative MPN patients(P<0.05).The levels of CD3^(+)and CD4^(+)were negatively correlated with poor prognosis of Ph-negative MPN patients(P<0.01).Conclusion The levels of inflammatory factors and T lymphocyte subsets were closely related to the prognosis of Ph-negative MPN patients.

关 键 词：费城染色体 骨髓增殖性肿瘤 炎症因子 T淋巴细胞亚群 

分 类 号：R733.3[医药卫生—肿瘤]