5-氨基酮戊酸光动力疗法治疗非黑色素瘤性皮肤癌患者的临床疗效  

Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in patients with-non-melanoma skin cancer

作　　者：李孝辉 张晓彬[1] 姜其学[1] LI Xiaohui;ZHANG Xiaobin;JIANG Qixue(Department of Dermatology,the Affiliated Hospital of Xinyang Vocational and Technical College,Xinyang 464000,He’nan,China)

机构地区：[1]信阳职业技术学院附属医院皮肤科,河南信阳4640000

出　　处：《癌症进展》2024年第19期2190-2193,共4页Oncology Progress

摘　　要：目的探讨5-氨基酮戊酸光动力疗法(ALA-PDT)治疗非黑色素瘤性皮肤癌(NMSC)患者的临床疗效。方法根据治疗方案的不同将52例NMSC患者分为A组(25例)和B组(27例),A组患者接受手术治疗,B组患者在A组的基础上接受ALA-PDT治疗。比较两组患者的临床疗效、血清学指标[转录中介因子1-γ(TIF1-γ)、Nodal、白细胞介素-1β(IL-1β)、转化生长因子-β1(TGF-β1)]、皮损面积、生活质量[生活质量综合评定问卷-74(GQOLI-74)]及外观满意度。结果B组患者的总有效率、外观总满意度均高于A组,差异均有统计学意义(P﹤0.05)。治疗后4周,两组患者TIF1-γ、Nodal、IL-1β、TGF-β1水平均低于本组治疗前,皮损面积均小于本组治疗前,GQOLI-74各维度评分均高于本组治疗前,B组患者TIF1-γ、Nodal、IL-1β、TGF-β1水平均低于A组,皮损面积小于A组,GQOLI-74各维度评分均高于A组,差异均有统计学意义(P﹤0.05)。结论ALA-PDT治疗NMSC患者效果较好,可降低血清学指标水平,减小皮损面积,提高患者外观满意度和生活质量。Objective To investigate the clinical efficacy of 5-aminolevulinic acid photodynamic therapy(ALA PDT)in patients with non-melanoma skin cancer(NMSC).Method A total of 52 NMSC patients were divided into group A(25 cases)and group B(27 cases)according to different treatment regimens.Patients in group A received surgical treatment,and patients in group B received ALA-PDT treatment on the basis of group A.The clinical efficacy,serological indexes[transcriptional intermediary factor 1-γ(TIF1-γ),Nodal,interleukin-1β(IL-1β),transforming growth fac-torβ1(TGF-β1)],area of skin lesions,quality of life[generic quality of life inventory-74(GQOLI-74)]and appearance satisfaction were compared between the two groups.Result The total effective rate and total appearance satisfaction rate in group B were higher than those in group A,and the differences were statistically significant(P<0.05).At 4 weeks after treatment,the levels of TIF1-γ,Nodal,IL-1βand TGF-β1 in two groups were lower than those before treatment,the area of skin lesions were smaller than those before treatment,the dimensional scores of GQOLI-74 were higher than those be-fore treatment,the levels of TIF1-γ,Nodal,IL-1βand TGF-β1 in group B were lower than those in group A,the area of skin lesions was smaller than that in group A,the dimensional scores of GQOLI-74 were higher than those in group A,and the differences were statistically significant(P<0.05).Conclusion ALA-PDT is effective in the treatment of NMSC patients,which can reduce the level of serological indexes,reduce the area of skin lesions,and improve the appearance satisfaction and quality of life of patients.

关 键 词：非黑色素瘤性皮肤癌 5-氨基酮戊酸光动力疗法 疗效 

分 类 号：R739.5[医药卫生—肿瘤]