两种血清标志物与老年急性脑梗死患者脑白质病变的相关性研究  

Correlation of serum ADAMTS-4 and aβ2-GP1 levels with white matter lesions in elderly patients with acute cerebral infarction

作　　者：纳文丽 白向东[1] 保砚 Na Wenli;Bai Xiangdong;Bao Yan(Department of Neurology,Yinchuan First People's Hospital,Yinchuan 750001,Ningxia Hui Autonomous Region,China)

机构地区：[1]银川市第一人民医院神经内科,750001 [2]银川市第二人民医院急诊医学科

出　　处：《中华老年心脑血管病杂志》2024年第11期1325-1328,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：银川市科技计划项目(2020-SF-006)。

摘　　要：目的 探讨血清血小板反应蛋白解整合素金属肽酶4(A disintegrin and metalloproteinase with thrombospondin motifs 4,ADAMTS-4)、抗β2糖蛋白1抗体(anti-β2 glycoprotein 1 antibody, aβ2-GP1)水平与老年急性脑梗死患者脑白质病变(white matter lesions, WML)的相关性。方法 回顾性收集2022年1月至2024年1月在银川市第一人民医院神经内科就诊的老年急性脑梗死患者200例,根据Fazekas评分标准将所有患者分为对照组(32例),轻度组(96例),中度组(49例),重度组(23例),对比各组患者神经功能以及血清ADAMTS-4和aβ2-GP1水平。结果 重度组美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale, NIHSS)评分,血清ADAMTS-4和aβ2-GP1水平明显高于对照组、轻度组和中度组(P<0.05),中度组NIHSS评分,血清ADAMTS-4和aβ2-GP1水平明显高于对照组和轻度组(P<0.05),轻度组NIHSS评分,血清ADAMTS-4和aβ2-GP1水平明显高于对照组(P<0.05)。血清ADAMTS-4和aβ2-GP1与WML程度呈明显正相关(P<0.05)。血清ADAMTS-4和aβ2-GP1是老年急性脑梗死患者发生WML的影响因素(OR=2.149,95%CI:1.375~3.360,P=0.001;OR=1.702,95%CI:1.185~2.446,P=0.004)。结论 血清ADAM TS-4和aβ2-GP1水平与老年急性脑梗死患者WML以及神经损伤的严重程度密切相关。Objective To explore the correlation of serum levels of ADAMTS-4 and aβ2-GP1 antibody with WML in elderly patients with ACI.Methods A retrospective study was conducted on 200 elderly ACI patients admitted in Department of Neurology of from January 2022 to January 2024.Based on Fazekas scoring,they were categorized into the control group(n=32),mild group(n=96),moderate group(n=49),and severe group(n=23).Their neurological function and serum levels of ADAMTS-4 and aβ2-GP1 were compared among the different groups.Results The NIHSS score and serum levels of ADAMTS-4 and aβ2-GP1 were significantly higher in the severe group than the moderate group,mild group and control group in order,and statistical difference were observed among them(P<0.05).Serum ADAMTS-4 and aβ2-GP1 levels were significantly positively correlated with the severity of WML(P<0.05).Serum ADAMTS-4 and anti-β2-GP1 were influencing factors for the occurrence of WML in elderly ACI patients(OR=2.149,95%CI:1.375-3.360,P=0.001;OR=1.702,95%CI:1.185-2.446,P=0.004).Conclusion The levels of serum ADAMTS-4 and aβ2-GP1 are closely related to the severity of WML and nerve damage in elderly ACI patients.

关 键 词：脑梗死 脑白质病 数据相关性 抗Β2糖蛋白1抗体 

分 类 号：R743.33[医药卫生—神经病学与精神病学]