清解扶正方加味联合美沙拉嗪治疗大肠湿热型溃疡性结肠炎35例  

35 Cases of Ulcerative Colitis of Damp Heat in the Large Intestine Treated with Modified Qingjie Fuzheng Prescription Combined with Mesalazine

作　　者：谢芳婧 林久茂[1,3] 赵锦燕 黄彬[1] 陈勇 XIE Fangjing;LIN Jiumao;ZHAO Jinyan;HUANG Bin;LIN Minghe;CHEN Yong(College of Integrative Medicine,Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350122,China;The Second Hospital of Longyan,Longyan,Fujian 364000,China;Fujian Key Laboratory of Integrative Medicine on Geriatrics,Fuzhou,Fujian 350122,China)

机构地区：[1]福建中医药大学中西医结合学院中西医结合研究院,福建福州350122 [2]龙岩市第二医院,福建龙岩364000 [3]福建省中西医结合老年性疾病重点实验室,福建福州350122

出　　处：《福建中医药》2024年第10期5-8,共4页Fujian Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81774121);福建省自然科学基金项目(2022J01368,2021J01939);陈可冀中西医结合发展基金项目(CKJ2022004)。

摘　　要：目的观察清解扶正方加味联合美沙拉嗪治疗大肠湿热型溃疡性结肠炎(UC)的临床疗效。方法选取2023年1—11月在龙岩市第二医院消化内科门诊及住院的大肠湿热型UC患者70例,采用随机数字表法分成对照组和治疗组各35例,对照组给予美沙拉嗪肠溶片口服,治疗组予清解扶正方加味联合美沙拉嗪肠溶片口服,2组疗程均为3个月。比较2组治疗前后中医证候积分、改良梅奥(Mayo)评分、肠道黏膜病变Baron评分及血清白细胞计数(WBC)、C反应蛋白(CRP)、红细胞沉降率(ESR)变化情况。结果与治疗前比较,治疗后2组中医证候积分、Mayo评分、Baron评分及血清WBC、CRP、ESR均下降(P<0.05);且治疗后治疗组上述指标较对照组均显著降低(P<0.05)。结论清解扶正方加味联合美沙拉嗪治疗大肠湿热型UC,可显著缓解患者临床症状,减轻肠道炎症反应,提高临床疗效。Objective:To observe the clinical efficacy of modified Qingjie Fuzheng Prescription combined with mesalazine in the treatment of ulcerative colitis(UC)of damp heat in the large intestine.Method:70 UC patients with damp heat in the large intestine who were admitted to the Gastroenterology Department of Longyan Second Hospital from January to November 2023 were randomly divided into control group and treatment group,with 35 patients in each group.The control group received oral mesalazine entericcoated tablets,while the treatment group received oral administration of modified Qingjie Fuzheng Prescription combined with mesalazine enteric coated tablets.The treatment period for both groups was 3 months.The changes in traditional Chinese medicine syndrome scores,modified Mayo score,Baron score for intestinal mucosal lesions,serum white blood cell count(WBC),erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)between two groups were compared before and after treatment.Results:Compared with pre-treatment situation,the scores of traditional Chinese medicine syndrome,Mayo scores,Baron scores,the levels of serum WBC,ESR,and CRP in both groups decreased after treatment(P<0.05);Compared with the control group after treatment,traditional Chinese medicine syndrome scores,Mayo scores,Baron scores,as well as the levels of serum WBC,ESR,and CRP in the treatment group decreased(P<0.05).Conclusion:Modified Qingjie Fuzheng Prescription combined with mesalazine can significantly alleviate clinical symptoms,reduce intestinal inflammatory reactions,and improve clinical efficacy in patients with colorectal damp heat type UC.

关 键 词：溃疡性结肠炎 大肠湿热证 清解扶正方加味 美沙拉嗪 

分 类 号：R574.62[医药卫生—消化系统]