从低度炎症角度论述腹泻型肠易激综合征相关性的中西医研究进展  

Progress of Chinese and Western Medicine Research on Correlation of Diarrheal Irritable Bowel Syndrome from the Perspective of Low-Grade Inflammation

作　　者：高永泽 苏海霞 张晓刚[1] 尉戎戎 刘黎明 赫子娇 付兆媛 GAO Yongze;SU Haixia;ZHANG Xiaogang;YU Rongrong;LIU Liming;HE Zijiao;FU Zhaoyuan(Gansu University of Chinese Medicine,Lanzhou 730000;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃中医药大学附属医院,兰州730020

出　　处：《中药药理与临床》2024年第9期113-120,共8页Pharmacology and Clinics of Chinese Materia Medica

基　　金：2022年陇原青年创新创业人才项目;甘肃省兰州市城关区科技计划项目(编号:2021JSCX0008);中西医结合学科2023年度“双一流”科研重点项目暨甘肃省中医药防治慢性疾病重点实验室开放课题(编号:GSSYLXM-05);甘肃中医药大学附属医院院内创新基金项目(编号:gzfy-2020-11);甘肃中医药大学2023年研究生创新创业基金项目。

摘　　要：近年来研究发现腹泻型肠易激综合征(Irritable bowel syndrome,IBS)是肠易激综合征(IBS with predominant diarrhea,IBS-D)中最为常见的类型之一,其发病机制复杂尚未完全明确。对症治疗时短期药物疗效尚可,但长期效果不佳,停药后易反复。近年来,中医药被证明在治疗腹泻型肠易激综合征中临床疗效显著,中医药多靶点、多途径、多通路的治疗机制可以通过降低肠道低度炎症,缓解腹泻型肠易激综合征的临床症状。结合目前最新专家共识认为低度炎症是影响腹泻型肠易激综合征患者发病机制的重要因素,本文通过检索近年来国内外相关文献,尝试从不同角度归纳总结低度炎症对于IBS-D的影响,发现其潜在的干预机制和治疗价值,为中西医结合治疗IBS-D提供理论参考和依据。Recent studies have found that diarrheal irritable bowel syndrome is one of the most common types of irritable bowel syndrome.Its pathogenesis is complex and multidimensional and is not fully understood.Short-term symptomatic treatment with the drug has certain efficacy but poor long-term effect,and the disease is easy to repeat after withdrawal.In recent years,traditional Chinese medicine has been proven to have significant clinical efficacy in the treatment of diarrheal irritable bowel syndrome.The multi-target,multi-approach,and multi-pathway therapeutic mechanism of traditional Chinese medicine can alleviate the clinical symptoms of diarrheal irritable bowel syndrome by reducing lowgrade intestinal inflammation.According to the latest expert consensus,low-grade inflammation is an important factor affecting the pathogenesis of diarrheal irritable bowel syndrome.By searching the relevant literature in China and abroad in recent years,this paper attempted to explore the effects of low-grade inflammation on diarrheal irritable bowel syndrome from different perspectives and find its potential intervention mechanism and therapeutic value,so as to provide a theoretical reference and basis for the treatment of diarrheal irritable bowel syndrome with both Chinese and Western medicine.

关 键 词：腹泻型肠易激综合征 低度炎症 中医药 综述 

分 类 号：R574[医药卫生—消化系统]