2017—2023年天津市食源性疾病沙门菌血清型及耐药性分析  

Serotyping and drug resistance of Salmonella isolated from foodborne diseases in Tianjin,2017-2023

作　　者：于爱萍 李闻[1,2] 张维 刘广文[1,2] 鹿晓慧 郑宝璐[1,2] 李晓燕 YU Ai-ping;LI Wen;ZhANG Wei;LIU Guang-wen;LU Xiao-hui;ZHENG Bao-lu;LI Xiao-yan(Institute of Microbiology,Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China;不详)

机构地区：[1]天津市疾病预防控制中心微生物检验检测所,天津300011 [2]天津市传染病病原微生物重点实验室

出　　处：《环境与健康杂志》2024年第9期799-803,F0003,共6页Journal of Environment and Health

基　　金：天津市卫生健康科技项目(TJWJ2022QN093);天津市卫生健康委重点项目(TJWJ2022ZD010)。

摘　　要：目的通过对2017—2023年天津市食源性疾病主动监测沙门菌血清型分布和耐药情况进行分析,为食源性疾病沙门菌感染的防控提供参考依据。方法依据国家食品安全风险评估中心《食源性疾病监测工作手册》要求,对2017—2023年天津市食源性疾病腹泻患者样本进行分离鉴定、血清学分型。结果2017—2023年收集820株沙门菌,患者男女比例为1.12∶1。不同年龄分组中,18~60岁年龄组检出构成最多。共分为60种血清型,主要血清型分别为肠炎沙门菌(53.29%),鼠伤寒沙门菌(15.37%),鼠伤单相变种沙门菌(4.02%)和伦敦沙门菌(2.80%)。药敏结果显示沙门菌对氨苄西林耐药率最高,为75.73%,对亚胺培南最为敏感,耐药率为1.95%。对头孢类抗生素中,一代头孢抗生素头孢唑啉耐药率最高,为39.76%。沙门菌对氨苄西林、氨苄西林舒巴坦、环丙沙星的耐药率有上升趋势,各年差异有统计学意义(P<0.05)。多重耐药率为67.44%,多重耐药表型较为广泛。结论天津市食源性疾病监测沙门菌,血清型别较多,肠炎沙门菌为优势型别。对常见抗生素耐药程度较高,多重耐药情况较为严重,应加强持续性监测。Objective To investigate the serotype and drug resistance characteristics of Salmonella isolated from patients with foodborne diseases in Tianjin during 2017 to 2023,and provide insights into management of Salmonella infections.Methods Salmonella isolated from stool samples of foodborne diseases patients in Tianjin from 2017 to 2023.Serotype and antimicrobial susceptibility test was according to the manual of foodborne disease surveillance.Results A total of 820 strains of Salmonella were detected and the male to female ratio of the positive cases was 1.12∶1.Among different age groups,the 18-60-year group has the highest detected composition.A total of 60 serotypes were characterized in 820 Salmonella isolates,and the main serotypes serotypes were S.Enteritidis(53.29%),S.Typhimurium(15.37%),S.Typhimurium monophasic variant(4.02%)and S.London(2.80%).The resistance rate of Salmonella was higher to ampicillin(75.73%)and sensitive to imipenem(1.95%).The resistance rate of among cephalosporin antibiotics,the first-generation cephalosporin antibiotic cefazolin had the highest resistance rate,at 39.76%.The resistance rate of Salmonella to ampicillin,ampicillin sulbactam,and ciprofloxacin presenting an upward trend.And the difference between years was statistically significant(P<0.05).The multidrug-resistant rate was 67.44%,the multidrug-resistant phenotype is relatively widespread.Conclusion There are multiple serotypes and S.Enteritidis being the most dominant type.The multidrug-resistance rate of the Salmonella strains was high,indicating a serious drug resistance situation.Monitoring should be strengthened high proportions.

关 键 词：沙门菌 血清型 耐药性 

分 类 号：R[医药卫生]