RNA N6甲基腺嘌呤修饰在肿瘤免疫逃逸中的研究进展  

Progress of RNA N6-methyladenosine modification in tumor immune evasion

作　　者：杨嘉禾 戴烨阳 陈程 褚晓源 Yang Jiahe;Dai Yeyang;Chen Cheng;Chu Xiaoyuan(Department of Medical Oncology,Nanjing Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210002,China)

机构地区：[1]南京大学医学院附属金陵医院肿瘤科,南京210002

出　　处：《肿瘤研究与临床》2024年第9期709-712,共4页Cancer Research and Clinic

摘　　要：肿瘤免疫贯穿肿瘤发生、发展的全过程,并且影响着肿瘤患者的预后。免疫抑制性肿瘤微环境、肿瘤细胞免疫原性降低可以帮助肿瘤细胞逃避T细胞的攻击,发生免疫逃逸。N6甲基腺嘌呤是真核生物细胞信使RNA最常见的修饰之一,参与肿瘤的发生、转移以及耐药。近年来研究发现,N6甲基腺嘌呤对肿瘤的免疫逃逸具有重要的调控作用。现总结免疫细胞和肿瘤细胞内N6甲基腺嘌呤修饰在肿瘤免疫逃逸中的作用和相关分子机制,探讨靶向N6甲基腺嘌呤调节分子联合免疫治疗对提高抗肿瘤免疫疗效的潜在价值和挑战,以期为肿瘤免疫治疗提供新的思路。Tumor immunity permeates the entire process of tumorigenesis and development,and influences the prognosis of patients.Immunosuppressive tumor microenvironment and reduced immunogenicity of tumor cells can help tumor cells escape from T cell attack,leading to immune evasion.N6-methyladenosine,one of the most common modifications of eukaryotic messenger RNA,has been reported to regulate tumorigenesis,metastasis and drug resistance.Recent studies revealed that N6-methyladenosine plays an important role in tumor immune evasion.This article summarizes the role and molecular mechanisms of N6-methyladenosine modification in tumor immune evasion in immune cells and tumor cells,and discusses the potential value and challenges of targeting N6-methyladenosine regulatory molecules in combination with immunotherapy to improve anti-tumor efficacy,in order to provide new ideas for tumor immunotherapy.

关 键 词：肿瘤 免疫 N6甲基腺嘌呤修饰 肿瘤逃逸 

分 类 号：R730.51[医药卫生—肿瘤]