多巴胺能神经元内质网-线粒体轴定位蛋白DJ-1、PINK1、Parkin在帕金森病中的作用机制  

Mechanism of endoplasmic reticulum-mitochondrial axis localization proteins DJ-1,PINK1 and Parkin in Parkinson’s disease

作　　者：韩政阳 梁建庆 董海玉 王佳华 许晨璐 李斐 HAN Zhengyang;LIANG Jianqing;DONG Haiyu;WANG Jiahua;XU Chenlu;LI Fei(School of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou,Gansu,730101,China;Dunhuang Medicine and Transformation Key Laboratory of Ministry of Education,Lanzhou,Gansu,730000,China)

机构地区：[1]甘肃中医药大学基础医学院,甘肃兰州730101 [2]敦煌医学与转化教育部重点实验室,甘肃兰州730000

出　　处：《甘肃中医药大学学报》2024年第5期73-78,共6页Journal of Gansu University of Chinese Medicine

基　　金：国家自然科学基金地区项目(82160929,81660767);2021年度甘肃省科技厅第十一批省级科技计划自然科学基金(自筹经费)项目(21JR11RA143);2021年度甘肃省教育厅青年博士基金项目(2021QB-077);敦煌医学与转化教育部重点实验室开放课题(DHYX22-06);甘肃省中医药研究中心开放课题(zyzx-2020-zx20)。

摘　　要：查阅相关文献,从蛋白质/核酸脱糖苷(DJ-1)、磷酸酶张力蛋白同源物诱导的假定蛋白激酶1(PINK1)、E3泛素连接酶(Parkin)的结构,分布及DJ-1、PINK1、Parkin与帕金森病(PD)的发病机制3个方面对多巴胺(DA)能神经元内质网-线粒体轴定位蛋白DJ-1、PINK1、Parkin在PD中的作用机制进行概述。结果发现,DJ-1、PINK1、Parkin参与内质网-线粒体的信号调节,并调控DA能神经元,从而引发一系列神经病理学特征,如线粒体功能障碍、氧化应激、细胞凋亡等,继而引发PD。但关于DJ-1、PINK1、Parkin参与PD致病机制的研究较少,详细的发病途径与病理机制还需进一步研究,以便为防治PD提供新的研究思路。By referencing relevant literature,this paper provides a summary of the mechanism of action of endoplasmic reticulum-mitochondrial axonal localization proteins DJ-1,PINK1,and Parkin in Parkinson's disease(PD)from three aspects:protein/nucleic acid deglucoside structure(DJ-1),PTEN-induced putative protein kinase 1(PINK1),E3 ubiquitin ligase(Parkin),distribution of DJ-1,PINK1,Parkin and their pathogenesis of PD.The results indicate that DJ-1,PINK1,and Parkin are involved in the signal regulation of endoplasmic reticulum and mitochondria.They regulate daergic neurons,thus triggering a series of neuropathological features such as mitochondrial dysfunction,oxidative stress,and apoptosis which then lead to PD.However,there is limited research on the pathogenesis of PD involving DJ-1,PINK1,and Parkin.Further studies are needed to explore the detailed pathogenesis and pathological mechanisms in order to provide new research ideas for the prevention and treatment of PD.

关 键 词：帕金森病 多巴胺 内质网-线粒体轴 蛋白质/核酸脱糖苷 PTEN诱导的假定蛋白激酶1 E3泛素连接酶 作用机制 

分 类 号：R742.5[医药卫生—神经病学与精神病学]