以静脉血提取富血小板纤维蛋白支架在恒牙牙髓血运重建中的应用  

Application of platelet-rich fibrin scaffolds extracted from venous blood in revascularization of pulp of permanent teeth

作　　者：苏彬 于莉 王盼盼 田娅珍 王晓琴 张新园 SU Bin;YU Li;WANG Pan-pan;TIAN Ya-zhen;WANG Xiao-qin;ZHANG Xin-yuan(The First Department of Endodontics,Urumqi Stomatological Hospital,Xijiang Urumqi 830000,China)

机构地区：[1]乌鲁木齐市口腔医院牙体牙髓一科,新疆乌鲁木齐830000

出　　处：《临床口腔医学杂志》2024年第10期610-614,共5页Journal of Clinical Stomatology

基　　金：乌鲁木齐市卫生健康委员会科技计划项目(202158)。

摘　　要：目的:探讨以静脉采血提取的液状注射型富血小板纤维蛋白作为支架材料在恒牙牙髓血运重建患者中的应用效果。方法:选择2021年5月~2023年5月乌鲁木齐市口腔医院牙体牙髓一科收治的恒牙牙髓血运重建患者62例为研究对象,信封随机法随机分为两组,各31例。对照组以根尖引血提取的液状注射型富血小板纤维蛋白作为支架,观察组采用静脉采血提取的液状注射型富血小板纤维蛋白作为支架。两组均完成12个月随访,比较两组牙根长度、牙本质壁厚度、根尖孔直径、牙根区域面积、根管区域面积的变化、视觉模拟疼痛(visual analogue scale,VAS)评分、治疗满意度及并发症发生率。结果:经过12个月随访,两组干预后均获得良好的治疗效果。观察组牙根长度、牙本质壁厚度、根尖孔直径、牙根区域面积高于对照组;根管区域面积低于对照组(P<0.05)。两组干预后疼痛减轻,治疗满意度得到提高;观察组VAS评分低于对照组;咬合度、整体美观度、牙齿色泽及咀嚼能力得分高于对照组(P<0.05)。两组并发症比较无统计学差异(P>0.05)。结论:采用静脉采血提取的液状注射型富血小板纤维蛋白作为支架用于恒牙牙髓血运重建中效果良好,能促进根管长度增加及根管壁增厚,有助于减轻患者疼痛,提高治疗满意度,且未增加并发症发生率,值得推广应用。Objective:To investigate the application effect of“liquid injection type platelet-rich fibrin extracted from venous blood collection”as scaffold material in patients with permanent pulp revascularization.Methods:A total of 62 patients with permanent dental pulp revascularization admitted to the First Department of Endodontics of Urumqi Stomatological Hospital from May 2021 to May 2023 were selected as the subjects,and were randomly divided into two groups with 31 cases in each group by envelope random method.The control group used liquid injectable platelet rich fibrin extracted from“apical blood transfusion”as the scaffold,and the observation group used“liquid injectable platelet rich fibrin extracted from intravenous blood collection”as the scaffold.Both groups completed 12 months of follow-up.The root length,dentin wall thickness,apical pore diameter,root area,root canal area,visual analogue pain(visual analogue scale,VAS)score,treatment satisfaction and complication rate were compared between the two groups.Results:After 12 months of follow-up,both groups obtained good therapeutic effect after intervention.The root length,dentin wall thickness,apical hole diameter and root area in observation group were higher than those in control group(P<0.05).The root canal area was lower than that of control group(P<0.05).After intervention,the pain of both groups was alleviated and the satisfaction of treatment was improved.VAS score of observation group was lower than that of control group(P<0.05).The scores of occlusal degree,overall aesthetics,tooth color and chewing ability were higher than those of control group(P<0.05).There was no statistical difference in complications between the two groups(P>0.05).Conclusion:The use of“liquid injectable platelet-rich fibrin extracted from venous blood collection”as a scaffold for permanent pulp revascularization has a good effect,can promote the increase of root canal length and root canal wall thickening,help reduce patients'pain,improve treatment satisfaction,

关 键 词：支架材料 恒牙牙髓血运重建 根尖引血 静脉采血 注射型富血小板纤维蛋白 

分 类 号：R781.05[医药卫生—口腔医学]