Immune surveillance of cytomegalovirus in tissues  

作　　者：Andrea Mihalić JelenaŽeleznjak Berislav Lisnić Stipan Jonjić Vanda JuranićLisnić Ilija Brizić 

机构地区：[1]Center for Proteomics,Faculty of Medicine,University of Rijeka,Rijeka,Croatia [2]Department of Biomedical Sciences,Croatian Academy of Sciences and Arts,Rijeka,Croatia

出　　处：《Cellular & Molecular Immunology》2024年第9期959-981,共23页中国免疫学杂志（英文版）

基　　金：supported by the National Institutes of Health(grant“Inflammation and Hearing Loss Following Congenital CMV Infection”[1 R01 DC015980-01A1])to S.Jonjić;a grant from the Scientific Centre of Excellence for Virus Immunology and Vaccines and co-financed by the European Regional Development Fund(“Strengthening the capacity of CerVirVac for research in virus immunology and vaccinology”[KK.01.1.1.01.0006])to S.Jonjić;the European Social Fund(grant“Biology of cytomegalovirus infection in developing brain and latency”[PZS-2019-02-7879])to I.Brizić;the Croatian Science Foundation(project numbers IP-2022-10-3371 to I.Brizić,IP-2020-02-3402 to B.Lisnićand IP-2022-10-2324 to V.JuranićLisnić).

摘　　要：Cytomegalovirus(CMV),a representative member of the Betaherpesvirinae subfamily of herpesviruses,is common in the human population,but immunocompetent individuals are generally asymptomatic when infected with this virus.However,in immunocompromised individuals and immunologically immature fetuses and newborns,CMV can cause a wide range of often long-lasting morbidities and even death.CMV is not only widespread throughout the population but it is also widespread in its hosts,infecting and establishing latency in nearly all tissues and organs.Thus,understanding the pathogenesis of and immune responses to this virus is a prerequisite for developing effective prevention and treatment strategies.Multiple arms of the immune system are engaged to contain the infection,and general concepts of immune control of CMV are now reasonably well understood.Nonetheless,in recent years,tissue-specific immune responses have emerged as an essential factor for resolving CMV infection.As tissues differ in biology and function,so do immune responses to CMV and pathological processes during infection.This review discusses state-of-the-art knowledge of the immune response to CMV infection in tissues,with particular emphasis on several well-studied and most commonly affected organs.

关 键 词：CYTOMEGALOVIRUS Immune response PATHOGENESIS Tissue MCMV HCMV 

分 类 号：R373[医药卫生—病原生物学]