RNA修饰在肿瘤线粒体中的作用:机遇与挑战  

Role of RNA modifications in tumor mitochondria:challenges and therapeutic opportunities

作　　者：周嘉旺 陶丽君 王红胜[1] Jiawang Zhou;Lijun Tao;Hongsheng Wang(School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhou 510006,China)

机构地区：[1]中山大学药学院,广州市510006

出　　处：《中国肿瘤临床》2024年第17期873-880,共8页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金面上项目(编号:82173833);国家资助博士后研究人员计划(编号:GZC20233241);中山大学高校基本科研业务费青年教师培育项目(编号:24qnpy183)资助。

摘　　要：碱基或核糖上发生化学基团修饰在RNA分子中普遍存在,这些RNA修饰行为可以通过影响基因表达从而调控肿瘤进展。深入研究RNA修饰在肿瘤进展中的作用,对于肿瘤机制的理解和干预策略的开发具有重要科学价值。线粒体在维持肿瘤细胞的异常代谢状态中扮演着至关重要的角色,近期研究提示RNA修饰与肿瘤线粒体之间存在着紧密联系,为干预肿瘤线粒体功能提供了重要机遇。本文聚焦于RNA修饰在肿瘤线粒体中的作用及相关机制,阐述线粒体自身及线粒体外RNA修饰对线粒体功能的影响,并探讨基于RNA修饰对肿瘤线粒体的干预策略,从而为代谢调控机制以及创新治疗策略提供更多的启示。Chemical modifications of nitrogenous bases or ribosemoieties are common in RNA molecules and these RNA modifications regulate tumor progression by modulating gene expression in malignancies.Therefore,delving into the role of RNA modifications in tumor progression is essential for understanding tumor progression mechanisms and developing intervention strategies.Mitochondria are crucial for maintaining the energy state of malignant tumor cells.Recent studies have indicated that RNA modifications and tumor mitochondria are closely connected,implying that mitochondrial function within tumors can be disrupted due to RNA modifications.This article focuses on the role and underlying mechanisms of RNA modifications in tumor mitochondria,offering crucial insights for a deeper understanding of the regulatory mechanisms of tumor metabolism and the development of new innovative therapeutic strategies.

关 键 词：RNA修饰 肿瘤 线粒体 

分 类 号：R730[医药卫生—肿瘤]