盐酸替罗非班氯化钠注射液辅助阿替普酶静脉溶栓治疗早期非大血管闭塞脑梗死的效果  

Effect of Tirofiban Hydrochloride and Sodium Chloride Injection Combined with Alteplase Intravenous Thrombolysis in the Treatment of Early Non-large Vessel Occlusion Cerebral Infarction

作　　者：周翔 庞红立[1] 严澎[1] 李文波[1] ZHOU Xiang;Pang Hongli;YAN Peng;LI Wenbo(Department of Neurointervention,Luoyang Central Hospital,Luoyang 471000,Henan,China)

机构地区：[1]洛阳市中心医院神经介入科,河南洛阳471000

出　　处：《中国药物滥用防治杂志》2024年第10期1895-1897,1902,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：河南省医学科技攻关计划(联合共建项目)(编号:LHGJ20220945)。

摘　　要：目的:观察阿替普酶静脉溶栓后应用替罗非班在治疗早期非大血管闭塞脑梗死患者中的安全性和疗效。方法:纳入2019年1月—2024年1月本院收治的早期非大血管闭塞脑梗死患者60例,按随机数字表法分为治疗组(30例)和对照组(30例)。治疗组予以替罗非班联合应用阿替普酶,对照组单纯应用阿替普酶。比较两组安全性、NIHSS评分及90天后MRS评分。结果:治疗组与对照组颅内出血、系统性出血、神经功能恶化死亡发生率比较,差异无统计学意义(P>0.05);治疗组24 h及7天NIHSS评分均低于对照组,差异有统计学意义(P<0.05);出院90天后,治疗组中良好预后占比为83.33%,高于对照组的56.67%,差异有统计学意义(P<0.05)。结论:在治疗早期非大血管闭塞脑梗死过程中,盐酸替罗非班氯化钠注射液辅助阿替普酶静脉溶栓较单纯应用阿替普酶更能降低NIHSS评分、MRS评分,提高患者的自理能力、改善预后。Objective:To observe the safety and efficacy of tirofiban hydrochloride and sodium chloride injection combined with alteplase intravenous thrombolysis in the treatment of early non-large vessel occlusion cerebral infarction.Methods:From January 2019 to January 2024,60 patients with early non-large vessel occlusion cerebral infarction admitted to our hospital were included and divided into treatment group(30 patients)and control group(30 patients)according to the random number table method.The treatment group was treated with tirofiban combined with alteplase,and the control group was treated with alteplase alone.The safety,NIHSS score and MRS score after 90 days were compared between the two groups.Results:There was no significant difference in the incidence of intracranial hemorrhage,systemic hemorrhage and neurological deterioration between the treatment group and the control group(P>0.05).The NIHSS scores of the treatment group at 24 h and 7 days were lower than those of the control group,and the differences were statistically significant(P<0.05).After 90 days of discharge,the proportion of good prognosis in the treatment group was 83.33%,which was higher than 56.67%in the control group,and the difference was statistically significant(P<0.05).Conclusion:In the treatment of early non-large vessel occlusion cerebral infarction,tirofiban hydrochloride and sodium chloride injection combined with alteplase intravenous thrombolysis can reduce NIHSS score and MRS score more than alteplase alone,improve patients'self-care ability and prognosis.

关 键 词：替罗非班 阿替普酶 单纯静脉应用 早期非大血管闭塞性脑梗死 自理能力 

分 类 号：R743.33[医药卫生—神经病学与精神病学]