Investigation on quality of life of hospitalized patients in China with digestive system malignancy  

作　　者：Kai-Lun Zhang Hong-Xia Xu Wei Li Jiu-Wei Cui Min Weng Qing-Hua Yao Zeng-Qing Guo Yi Ba Fu-Xiang Zhou Zhi-Kang Chen Su-Yi Li Qing-Chuan Zhao Chun-Ling Zhou Ming Liu Lan Zhou Han-Ping Shi Chun-Hua Song 

机构地区：[1]Department of Epidemiology and Statistics,College of Public Health,Zhengzhou University,Zhengzhou 450001,Henan,China [2]Department of Nutrition,Daping Hospital&Research Institute of Surgery,Third Military Medical University,Chongqing 400038,China [3]Cancer Center of the First Hospital of Jilin University,Changchun 130021,Jilin,China [4]Department of Clinical Nutrition,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan,China [5]Department of Integrated Traditional Chinese andWestern Medicine,Zhejiang Cancer Hospital and Key Laboratory of Traditional Chinese Medicine Oncology,Zhejiang Cancer Hospital,Hangzhou 310022,Zhejiang,China [6]Department of Medical Oncology,Fujian Cancer Hospital&Fujian Medical University Cancer Hospital,Fuzhou 350014,Fujian,China [7]Department of Gastrointestinal Oncology,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China [8]Department of Radiation and Medical Oncology,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei,China [9]Department of Colorectal and Anus Surgery,Xiangya Hospital of Central South University,Changsha 410008,Hunan,China [10]Department of Nutrition and Metabolism of Oncology,Affiliated Provincial Hospital of Anhui Medical University,Hefei 230031,Anhui,China [11]Department of Digestive Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,Shaanxi,China [12]Department of Clinical Nutrition,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China [13]Department of General Surgery,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China [14]Department of Nutrition,Third Affiliated Hospital of Kunming Medical College,Tumor Hospital of Yunnan Province,Kunming 650118,Yunnan,China [15]Center of Cancer Nutrition and Metabolism,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China [16]Henan Key Laboratory o

出　　处：《Journal of Nutritional Oncology》2024年第2期53-62,I0001,共11页肿瘤营养学杂志（英文）

基　　金：supported by the National KeyResearch and Development Program(No.2022YFC2009600 andNo.2022YFC2009601).

摘　　要：Background: The purpose of this study is to evaluate the quality of life(QoL) of hospitalized patients in China suffering from digestive system malignancies and to identify potential risk factors for a decrease in QoL.Methods: The European Organization for Research and Treatment Core Quality of Life questionnaire(EORTC QLQ-C30) was applied to evaluate the QoL of 23,519 patients with six digestive malignancies(esophageal cancer, gastric cancer, colorectal cancer, liver cancer, biliary tract cancer, and pancreatic cancer). A t test or analysis of variance was employed to analyze the total EORTC QLQ-C30 scale scores and domain scores of the EORTC QLQ-C30 scale among patients in different subgroups.Results: The average QoL score was 50.4 ± 10.8. The tumor type, age, sex, and TNM stage al had an impact on QoL ratings. Colorectal cancer patients had a better total QoL score(49.3 ± 10.3) and scores in the domains of functioning, with milder symptoms, except for diarrhea. Patients with biliary tract cancer(54.2 ± 12.3) and pancreatic cancer(54.2 ± 12.3) reported a poorer QoL, significant functional impairment, and more pronounced symptoms. Patients with esophageal cancer experienced the most severe financial difficulties(35.2 ± 27.5). Patients aged ≥65 years, women, and those with TNM stage Ⅲ/Ⅳ reported lower QoL. In addition, the disparities in total QoL scores and scores in specific domains were significant among patients with some types of tumors, and based on ethnicity, educational level, occupation, treatment(s) received, and place of residence.Conclusions: There is a need to focus on elderly individuals, those with low educational levels, and patients with progressive malignant tumors and to improve routine disease monitoring and symptom management to enhance the quality of life for patients with malignancies of the digestive system.

关 键 词：Quality of life Digestive system malignancy Cross-sectional study EORTC QLQ-C30 

分 类 号：R735[医药卫生—肿瘤]