降钙素受体表达与胃癌临床病理特征及预后的关系  

Relationship between calcitonin receptor expression and clinicopathologic features and prognosis of gastric cancer

作　　者：陈善勤 白傲祥 管佳佳 杭群 Chen Shanqin;Bai Aoxiang;Guan Jiajia;Hang Qun(Department of Gastrointestinal Surgery,The First Affiliated Hospital of Bengbu Medical University,Bengbu 233000,China)

机构地区：[1]蚌埠医科大学第一附属医院胃肠外科,蚌埠233000

出　　处：《中国综合临床》2024年第5期369-374,共6页Clinical Medicine of China

摘　　要：目的探讨降钙素受体(calcitonin receptor,CALCR)表达与胃癌患者临床病理特征及预后的关系。方法选取2014年1月至2017年11月在蚌埠医学院第一附属医院胃肠外科治疗的108例胃癌患者的临床资料进行回顾性分析,采用免疫组化法(immunohistochemistry,IHC)分析胃癌及癌旁组织中降钙素受体的表达差异,分析其表达与临床病理参数的关系及意义;利用K-M、ROC曲线评估CALCR表达对于患者术后生存率的影响以及预测术后5年生存率。计数资料组间率的比较采用χ^(2)检验,Kaplan-Meier法估计总生存期及无进展生存期,生存差异比较采用Log-rank法。结果CALCR主要表达于细胞质中,且CALCR在胃癌组织表达占比[62.04%(67/108)]高于癌旁组织[13.89%(15/108)],差异有统计学意义(χ^(2)=53.16,P<0.001)。CALCR高表达组胃癌患者组织浸润深度[91.04%(61/67)]、淋巴结转移率[73.1%(49/67)]及外周血CA19-9≥37 kU/L的比率[32.8%(22/67)]高于CALCR低表达组[63.41%(26/41)、53.7%(22/41),12.2%(5/41)],差异均有统计学意义(χ^(2)值分别为12.40、4.28、4.78,P值分别为<0.001、0.038、0.016)。K-M曲线及Log-rank检验结果显示,在胃癌患者中,CALCR高表达组患者术后5年生存率低于低表达组患者[11.9%(8/67)和43.9%(18/41),Log-rankχ^(2)=29.92,P<0.001]。ROC曲线结果显示:曲线下面积为0.772,敏感度:87.8%,特异度:53.7%,表明CALCR对于预测胃癌患者术后5年生存率具有较高价值。结论CALCR在胃癌组织中高表达并与患者肿瘤病理特征相关,CALCR高表达提示预后不佳,表明CALCR有希望成为评估胃癌患者生存预后的重要指标。ObjectiveTo explore the relationship between calcitonin receptor(CALCR)expression and clinicopathologic features and prognosis of gastric cancer patients.MethodsA retrospective analysis was performed to collect 108 samples of gastric cancer patients treated in Department of Gastrointestinal Surgery,First Affiliated Hospital of Bengbu Medical College from January 2014 to November 2017.Immunohistochemistry(IHC)was used to analyze the differential expression of calcitonin receptors in gastric cancer and adjacent tissues,and the relationship and significance between their expression and clinical pathological parameters were analyzed K-M and ROC curves were used to assess the K-M and ROC curves were used to evaluate the effect of CALCR expression on patients'postoperative survival and to predict the 5-year postoperative survival rate.The comparison of inter group rates in count data was performed usingχ^(2)test,and the Kaplan Meier method was used to estimate overall survival and progression free survival.The comparison of survival differences was performed using the Log-rank method test.ResultsCALCR was mainly expressed in the cytoplasm and its expression in gastric cancer tissues(62.04%(67/108))was higher than that in paracancerous tissues(13.89%(15/108)),and the differences were statistically significant(χ^(2)=53.16,P<0.001).The tissue infiltration depth(91.04%(61/67)),lymph node metastasis(73.1%(49/67)),and peripheral blood CA19-9(32.8%(22/67))in gastric cancer patients with high expression of CALCR were higher than those in the low expression group of CALCR(63.41%(26/41),53.7%(22/41),12.2%(5/41)),and the differences were statistically significant(χ2 values were 12.40,4.28,and 4.78;P values were<0.001,0.038,and 0.016).The results of K-M curve and Log-rank test showed that among gastric cancer patients,the postoperative 5-year survival rate of patients with high expression of CALCR was lower than that of patients with low expression(11.9%(8/67)and 43.9%(18/41),Log-rankχ^(2)=29.92,P<0.001).The results of the ROC

关 键 词：胃癌 降钙素受体 预后 临床病理特征 

分 类 号：R735.2[医药卫生—肿瘤]