基于中西医临床病证特点的胆管癌动物模型分析  

Analysis of animal model of cholangiocarcinoma based on its clinical symptoms of traditional Chinese and Western medicine

作　　者：王笑冉 赵文霞[2] 苗明三[1] WANG Xiaoran;ZHAO Wenxia;MIAO Mingsan(Henan University of Chinese Medicine,Zhengzhou 450046,China;The First Affiliated Hospital of Henan University of CM,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,郑州450046 [2]河南中医药大学第一附属医院,郑州450000

出　　处：《中华中医药杂志》2024年第10期5142-5146,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.82074038);岐黄学者(No.国中医药人教函2022-6);河南省重大公益专项(No.201300310100)。

摘　　要：胆管癌是一种病死率极高的消化道恶性肿瘤。建立符合中西医临床病证特点的胆管癌动物模型是研究其发生、发展和治疗的关键。因此,文章基于胆管癌中西医临床诊断标准,归纳总结现有的胆管癌动物模型的造模方法和模型特点,开展模型吻合度评价,提出模型完善建议。结果显示:现有动物模型多为单因素造模,与临床胆管癌多因素的致病特点不符;造模过程多以西医理论为指导,缺少中医致病因素的参与,病证结合模型少;模型评价依据西医病理学和细胞学检查,与临床中西医诊断标准存在差异,目前尚无公认的体现中医证型的造模方法。临床吻合度分析发现,移植性动物模型的中西医临床吻合度最高。未来仍需进一步改进胆管癌的造模方式,完善胆管癌动物模型的病证结合评价体系,为该疾病的基础研究提供更科学的动物模型载体。Cholangiocarcinoma is a malignant tumor of digestive tract with high mortality.The establishment of animal models of cholangiocarcinoma in accordance with the clinical characteristics of traditional Chinese and Western medicine is the key to the study of its occurrence,development and treatment.Therefore,this paper summarized the modeling methods and characteristics of the existing animal models of cholangiocarcinoma,carried out the evaluation of the coincidence degree of the model according to the clinical diagnostic criteria of traditional Chinese and Western medicine,and put forward some suggestions for improving the model.The results show that most of the existing animal models of cholangiocarcinoma are made by single factor,which is not consistent with the pathogenic characteristics of multiple factors of clinical cholangiocarcinoma;the modeling process is mostly guided by western medicine theory,lack of the participation of traditional Chinese medicine pathogenic factors,and few models of combination of disease and syndrome;the evaluation of the model is based on the pathological and cytological diagnosis of Western medicine,which is different from the clinical diagnostic criteria of traditional Chinese and Western medicine.The clinical coincidence degree analysis showed that the transplant animal models have the highest clinical coincidence degree of traditional Chinese and Western medicine.In the future,it is still necessary to further improve the modeling method of cholangiocarcinoma and improve the disease-syndrome combination evaluation system of cholangiocarcinoma animal models,so as to provide a more scientific animal model carrier for the basic research of the disease.

关 键 词：胆管癌 病证结合 动物模型 评价分析 

分 类 号：R735.8[医药卫生—肿瘤] R-332[医药卫生—临床医学]