间皮瘤早期诊断系统的建立及研究进展  

Establishment and research progress of early diagnosis system for pleural mesothelioma

作　　者：梅雯 杨晟杰 张也频 Mei Wen;Yang Shengjie;Zhang Yepin(Department of Pathology,The people's Hospital of Chuxiong Yi Autonomous Prefecture,Chuxiong 675000,China;Department of Thoracic Surgery,The Fourth Affilicated Hospital Dali University,Chuxiong 675000,China)

机构地区：[1]楚雄彝族自治州人民医院病理科,楚雄675000 [2]大理大学第四附属医院胸外科,楚雄675000

出　　处：《中华劳动卫生职业病杂志》2024年第10期793-800,共8页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：云南省科技厅地方高校联合专项面上项目(202301BA070001-26、202301BA070001-027);国家自然科学基金项目(81560458、31601155)。

摘　　要：胸膜间皮瘤(PMe)与接触石棉有关,尽管目前有许多间皮瘤的早期诊断工具,但由于临床症状和体征缺乏特异性,诊断仍较为困难,多数PMe患者被确诊时已为晚期。本文就PMe早期诊断策略方面的进展进行综述,这些策略有助于间皮瘤的早期诊断,研究重点集中在呼气分析、间皮瘤患者胸腔积液细胞学早期诊断、血清生物标志物及miRNA等。Pleural mesothelioma(PMe)was associated with asbestos exposure.The Diagnosis of PMe is difficult due to the lack of specificity of clinical signs and symptoms,although there are many tools available for early diagnosis of mesothelioma.Most PMe patients are diagnosed at an advanced stage.This article reviews advances in strategies for early diagnosis of mesothelioma,focusing on breath analysis,early diagnosis of pleural effusion cytology in patients with mesothelioma,serum biomarkers and miRNA.

关 键 词：间皮瘤 诊断 恶性间皮瘤 胸膜间皮瘤 早期诊断 微核糖核酸 

分 类 号：R734.3[医药卫生—肿瘤]