Intracellular checkpoints for NK cell cancer immunotherapy  

作　　者：Yingying Huang Zhigang Tian Jiacheng Bi 

机构地区：[1]CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [2]Department of Urology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China [3]Center for Genomic and Personalized Medicine,Guangxi Medical University,Nanning 530021,China [4]Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine,Nanning 530021,China [5]Guangxi Key Laboratory for Genomic and Personalized Medicine,Guangxi Key Laboratory of Colleges and Universities,Nanning 530021,China [6]Collaborative Innovation Center of Regenerative Medicine and Medical BioResource Development and Application,Guangxi Medical University,Nanning 530021,China [7]The CAS Key Laboratory of Innate Immunity and Chronic Disease,School of Basic Medical Sciences,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230027,China [8]Institute of Immunology,University of Science and Technology of China,Hefei 230027,China [9]Research Unit of NK Cell Study,Chinese Academy of Medical Sciences,Beijing 100864,China

出　　处：《Frontiers of Medicine》2024年第5期763-777,共15页医学前沿（英文版）

基　　金：supported by the National Key R&D Program of China(No.2020YFA0710802 to Jiacheng Bi);Guangdong Basic and Applied Basic Research Foundation(No.2021A1515110174 to Yingying Huang);the National Natural Science Foundation of China(No.82071768 to Jiacheng Bi).

摘　　要：Natural killer(NK)cells are key innate immune lymphocytes,which play important roles against tumors.However,tumor-infiltrating NK cells are always hypofunctional/exhaustive.On the one hand,this state is contributed by context-dependent interactions between inhibitory NK cell checkpoint receptors and their ligands,which usually vary in different tumor types and stages during tumor development.On the other hand,the inhibitory functions of intracellular checkpoint molecules of NK cells are more similar across different tumor types,representing common mechanisms limiting the potential of NK cell therapy.In this review,representative NK cell intracellular checkpoint molecules in different aspects of NK cell biology were reviewed,and therapeutic potentials were discussed by targeting these molecules to promote antitumor NK cell therapy.

关 键 词：genomic editing NK cell exhaustion immune checkpoint inhibitory molecules immune tolerance 

分 类 号：R730.51[医药卫生—肿瘤]