Epigenetic modifiers: catalytic or noncatalytic, that is the question  

作　　者：Yimin Liu Haitao Li 

机构地区：[1]State Key Laboratory of Molecular Oncology,Beijing Frontier Research Center for Biological Structure,School of Basic Medical Sciences,Tsinghua University,Beijing 100084,China [2]SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine,Shanxi Medical University,Taiyuan 030001,China [3]Tsinghua-Peking Center for Life Sciences,Beijing 100084,China

出　　处：《Frontiers of Medicine》2024年第5期941-943,共3页医学前沿（英文版）

摘　　要：Epigenetic modifiers are enzymes that catalyze covalent chemical modifications on chromatin and thus play important roles in setting relatively stable states for gene expression and cell identity.It has been widely observed that mutations in epigenetic modifiers cause various types of human diseases,such as developmental defects and cancers.Therefore,deciphering how the mutations affect functions of the epigenetic modifiers in developmental and pathological conditions is crucial for understanding the underlying mechanisms and for identifying potential therapeutic targets.

关 键 词：identity. MODIFIERS CATALYTIC 

分 类 号：O64[理学—物理化学]