苯达莫司汀联合利妥昔单抗治疗边缘区B细胞淋巴瘤继发结节性红斑1例并文献复习  

Erythema nodosum secondary to bendamustine combined with rituximab treatment in marginal zone B-cell lymphoma:A case report and literature review

作　　者：李玲丽 李佳惠 周城 邹彬镔 刘广花 黄康乐 雷平[1] 周明[1] 刘灿[1] LI Lingli;LI Jiahui;ZHOU Cheng;ZOU Binbin;LIU Guanghua;HUANG Kangle;LEI Ping;ZHOU Ming;LIU Can(Department of Hematology,Hunan Provincial People’s Hospital/First Affiliated Hospital of Hunan Normal University,Changsha 410008,China)

机构地区：[1]湖南省人民医院/湖南师范大学附属第一医院血液科,长沙410008

出　　处：《临床与病理杂志》2024年第7期1033-1038,共6页Journal of Clinical and Pathological Research

基　　金：湖南省自然科学基金(2024JJ9278);湖南省卫健委一般指导课题(202203043468)。

摘　　要：回顾分析1例边缘区B细胞淋巴瘤(marginal zone B-cell lymphoma,MZBL)患者接受苯达莫司汀联合利妥昔单抗(bendamustine and rituximab,BR)治疗后继发结节性红斑(erythema nodosum,EN)的临床资料,并结合文献总结EN的临床表现、病理特点、可能的病因和治疗方法。该患者61岁,女,经骨髓活检、淋巴结活检等诊断为MZBL,予BR方案治疗后出现皮肤改变,且伴有发热、咽痛、关节肌肉疼痛等症状,白细胞介素-6(interleukin 6,IL-6)明显增高,经皮肤活检确诊为EN,未发现感染证据,原发病部分缓解,EN与化学治疗药物相关,经甲泼尼龙等抗炎治疗后迅速控制,后未再出现此类不良反应。淋巴瘤患者治疗后出现皮肤红斑表现,需结合临床表现、皮肤活检,尽早识别病因进行治疗,并对患者进行长期随访。This study reviews the clinical data of a patient with marginal zone B-cell lymphoma(MZBL)who developed erythema nodosum(EN)following treatment with bendamustine and rituximab(BR).The clinical manifestations,pathological features,potential causes,and treatment methods of EN are summarized based on the literature.The patient,a 61-year-old woman,was diagnosed with MZBL through bone marrow and lymph node biopsies.After receiving BR therapy,she developed skin changes along with fever,sore throat,and joint/muscle pain.Her interleukin 6(IL-6)levels were significantly elevated,and a skin biopsy confirmed the diagnosis of EN.No evidence of infection was found,and the primary disease showed partial remission.EN was considered to be related to chemotherapy drugs,and it was quickly controlled with anti-inflammatory treatment using methylprednisolone.No recurrence of similar adverse reactions was observed afterward.In lymphoma patients with skin EN after treatment,it is essential to combine clinical symptoms with skin biopsy for early identification of the cause and prompt treatment.Long-term follow-up is also necessary.

关 键 词：结节性红斑 淋巴瘤 B细胞 

分 类 号：R733.1[医药卫生—肿瘤]