KLF7表达在前列腺癌筛查中的作用及其对预后风险的评估  

Effects of KLF7 expression on prostate cancer screening and assessment of prognostic risk

作　　者：张一冲 杨力媛 徐立业 许晓丽[1] ZHANG Yichong;YANG Liyuan;XU Liye;XU Xiaoli(Department of Pathology,Second Affiliated Hospital of Xingtai Medical College,Xingtai,Hebei,054000,China;Department of Clinical Laboratory,Second Affiliated Hospital of Xingtai Medical College)

机构地区：[1]邢台医学高等专科学校第二附属医院病理科,河北邢台054000 [2]邢台医学高等专科学校第二附属医院检验科

出　　处：《临床泌尿外科杂志》2024年第10期871-875,共5页Journal of Clinical Urology

基　　金：邢台市重点研发计划项目(No:2020ZC267)。

摘　　要：目的:探究Krüppel样因子7(Krüppel-like factor-7,KLF7)表达在前列腺癌(prostate cancer,PCa)筛查中的相互作用及其对预后风险的评估效能。方法:选取2021年1月—2023年12月于邢台医学高等专科学校第二附属医院就诊的PCa患者68例(PCa组)及良性前列腺增生(benign prostatic hyperplasia,BPH)患者52例(BPH组),比较2组患者总前列腺特异性抗原(total prostate-specific antigen,tPSA)、血脂血糖水平、KLF7表达情况,并采用Spearman相关性分析PCa组织中KLF7的表达与tPSA水平相关性、KLF7表达率与PCa预后指标的关系,采用受试者工作特征(receiver operating characteristic,ROC)曲线预测tPSA、KLF7在PCa中的诊断价值。结果:PCa组tPSA水平、KLF7的表达水平均显著高于BPH组(P<0.05),Spearman分析显示KLF7表达与tPSA水平呈显著正相关(r=0.329,P<0.001),KLF7表达率与PCa预后指标ISUP分级、临床分期具有显著相关性(P<0.05)。ROC结果显示,tPSA、KLF7预测PCa的曲线下面积分别为0.752、0.921(P<0.05),最佳截断值分别为21.29 ng/mL、1.30,灵敏度分别为77.6%、94.0%,特异度分别为64.2%、84.9%。本研究纳入的PCa患者共有16例灰区患者,KLF7对灰区PCa患者具有良好的诊断效能,灵敏度、特异度、阳性预测值、阴性预测值、准确度分别为85.4%、91.8%、81.2%、93.8%、89.9%。结论:KLF7表达在PCa筛查中具有良好的诊断效能,血清tPSA与KLF7均可作为PCa预后风险因素,其对PCa的诊断和治疗具有重要意义。Objective To explore the effects of Krüppel-like factor-7(KLF7)expression on prostate cancer(PCa)screening and assessment of prognostic risk.Methods We selected 68 PCa patients(PCa group)and 52 benign prostatic hyperplasia patients(BPH group).We compared tPSA,blood lipid and glucose,and KLF7 expression levels between the two groups.Spearman correlation analysis was used to examine the correlation between KLF7 expression and tPSA level in PCa tissues,and the association between KLF7 expression rate and PCa prognostic indicators.We used the receiver operating characteristic curve(ROC curve)to assess the diagnostic value of tPSA and KLF7 to PCa.Results The PCa group had significantly higher tPSA and KLF7 expression levels than the BPH group(P<0.05).Spearman correlation analysis showed a positive correlation between KLF7 expression and tPSA level(r=0.329,P<0.001).KLF7 expression was significantly related to ISUP grade and clinical stage of PCa(P<0.05).ROC results showed that the area under the curve of tPSA and KLF7 for predicting PCa were 0.752 and 0.921(P<0.05),and the best cut-off values were 21.29 ng/mL and 1.30,respectively.The specificity were 64.2%and 84.9%,and the sensitivity were 77.6%and 94.0%,respectively.A total of 16 patients with gray zone PCa were included in this study.KLF7 had good diagnostic efficacy for gray zone PCa patients,with sensitivity,specificity,positive prognostic value,negative prognostic value and accuracy of 85.4%,91.8%,81.2%,93.8%and 89.9%,respectively.Conclusion KLF7 expression has a good diagnostic efficacy in prostate cancer screening.Serum tPSA and KLF7 can be used as prognostic risk factors in PCa,which is of great significance for the diagnosis and treatment of PCa.

关 键 词：前列腺癌 前列腺特异性抗原 Krüppel样因子7 

分 类 号：R737.25[医药卫生—肿瘤]