(±)山豆根酮A10和A1的合成及抗氧化活性  

Synthesis and antioxidant activity of(+)euchrenone A10 and A1

作　　者：王晋 郭冬冬 张永坡[1] 殷丛丛 赵晋忠[1] WANG Jin;GUO Dong-dong;ZHANG Yong-po;YIN Cong-cong;ZHAO Jin-zhong(Department of Basic courses,Shanxi Agricultural University,Taigu 030801,China)

机构地区：[1]山西农业大学基础部,山西太谷030801

出　　处：《化学研究与应用》2024年第11期2583-2589,共7页Chemical Research and Application

基　　金：国家自然科学基金项目(82274363)资助。

摘　　要：以2,4,6-三羟基苯乙酮一水合物和对羟基苯甲醛为起始原料,经C-异戊烯基化反应、羟基保护、羟醛缩合、环合,脱保护合成了具有抗炎效果的天然产物山豆根酮A10和EuchrenoneA1,总收率分别为15.9%和12.8%。实验表明,山豆根酮A10具有一定的抗氧化活性。The efficient synthesis of two naturally occurring prenylated flavonoids,euchrenone A10 and euchrenone Al were obtained from p-hydroxybenzaldehyde and 2,4,6-trihydroxyacetophenone monohydrate through a series of steps including C-prenylation,hydroxyl group protection,aldol condensation,cyclization,and deprotection,with overall yields of 15.9%and 12.8%,respectively.Furthermore,their antioxidant activities were evaluated,revealing that euchrenone A10 exhibited superior antioxidant properties.

关 键 词：山豆根酮A10 Euchrenone A1 异戊烯基黄酮 全合成 抗氧化活性 

分 类 号：O626.3[理学—有机化学]