不同脉冲宽度刺激下无抽搐电休克治疗重度抑郁症的疗效及对外周血环状RNA表达的影响  

Clinical outcome of modified electroconvulsive therapy on major depression under different pulse width stimulation and its impact on peripheral blood circular RNA expression

作　　者：张迪 陈莹 丁会 李松涛 ZHANG Di;CHEN Ying;DING Hui;LI Songtao(Department of Psychiatry,Shaoxin Seventh People's Hospital,Shaoxin 312000,CHINA)

机构地区：[1]绍兴市第七人民医院精神科,浙江312000

出　　处：《江苏医药》2024年第10期990-994,共5页Jiangsu Medical Journal

基　　金：浙江省医药卫生科技计划项目(2023KY1272、2024KY1735)。

摘　　要：目的探讨不同脉冲宽度刺激下无抽搐电休克治疗重度抑郁症患者的疗效及对外周血环状RNA(circRNA)表达的影响。方法86例重度抑郁症患者随机分为两组,每组43例。A组和B组无抽搐电休克治疗的脉冲宽度分别为4ms+1ms+4ms和2ms+1ms+2ms,共治疗6次。比较两组治疗后简易智力状态检查量表(MMSE)评分、汉密尔顿抑郁量表17项(HAMD-17)评分及减分率、日常生活能力量表(ADL)评分、外周血circRNA表达以及临床总有效率。结果治疗后,两组MMSE总分及各项评分、ADL评分均较治疗前升高,且B组高于A组(P<0.05)。B组治疗3次后HAMD-17评分减分率高于A组(P<0.05)。治疗后,B组外周血hsa_circRNA_103102、hsa_circRNA_103704表达高于A组,hsa_circRNA_104597表达低于A组(P<0.05)。B组临床总有效率高于A组(P<0.05)。结论2ms+1ms+2ms脉冲宽度刺激下无抽搐电休克治疗重度抑郁症患者可使hsa_circRNA_103102和hsa_circRNA_103704表达升高、hsa_circRNA_104597表达降低,且临床疗效更佳。Objective To explore the clinical outcome of modified electroconvulsive therapy under different pulse width stimulation in the patients with major depression and its impact on peripheral blood circular RNA(circRNA)expression.Methods Eighty-six patients with major depression were randomly divided into two groups with 43 cases each.Group A and group B accepted modified electroconvulsive therapy under pulse width stimulation of 4 ms+1 ms+4 ms and 2 ms+1 ms+2 ms,respectively.A total of 6 treatments were administered.Hamilton depression scale-17(HAMD-17)score and reduction rate,mini-mental state examination(MMSE)score,activity of daily living scale(ADL)score,peripheral blood circRNA expression and total clinical effective rate were compared between the two groups.Results Compared to before treatment,the total and subdomain MMSE scores and ADL score were higher after treatment in both groups,which in group B were higher than those in group A(P<0.05).After 3 treatments,the HAMD-17 score reduction rate in group B was higher than that in group A(P<0.05).After treatment,the expressions of hsa_circRNA_103102 and hsa_circRNA_103704 in peripheral blood were higher,while the expression of hsa_circRNA_104597 was lower,in group B than those in group A(P<0.05).The total clinical effective rate in group B was higher than that in group A(P<0.05).Conclusion Under 2ms+1ms+2ms pulse width stimulation,modified electroconvulsive therapy can increase the expressions of hsa_circRNA_103102 and hsa_circRNA_103704,decrease the expression of hsa_circRNA_104597 in the patients with major depression,and achieve better clinical outcome.

关 键 词：重度抑郁症 无抽搐电休克治疗 脉冲宽度 环状核糖核酸 

分 类 号：R749[医药卫生—神经病学与精神病学]