缺氧诱导因子-1α和核因子E2相关因子2与帕金森病相关性的研究进展  

Progress in correlation between hypoxia inducible factor-la,nuclear factor erythroid 2-related factor 2 and Parkinson's disease

作　　者：严露萱 朱爱琴[1] Yan Luruan;Zhu Aiqin(Department of Geriatrics,Qinghai People's Hospital,Xining 810000,China;Graduate School of Qinghai University,Xining 810000,China)

机构地区：[1]青海省人民医院老年医学科,西宁810000 [2]青海大学研究生院,西宁810000

出　　处：《中华老年医学杂志》2024年第11期1490-1495,共6页Chinese Journal of Geriatrics

基　　金：青海省老年疾病临床医学研究中心(2021-SF-133);青海省卫生健康系统重点课题(2021-wjzd-03)。

摘　　要：帕金森病(PD)病因复杂, 机制尚不清楚, 由于涉及基因、环境和衰老, 寻找共同的因素是确定干预目标的关键。缺氧在自然环境和疾病状态中普遍存在, 它被认为与PD的病因密切相关。缺氧可能增加致病蛋白α-突触核蛋白的表达和聚集, 通过多靶点来影响PD的发生和发展。缺氧诱导因子-1α(HIF-1α)、核因子E2相关因子2(Nrf2)与缺氧密切相关, 是机体调节氧化应激的重要信号通路, 其机制可能与减少神经元凋亡、降低炎性反应和减轻氧化应激有密切关系。研究显示, 激活HIF-1α、Nrf2因子相关信号通路后可保护黑质多巴胺能神经元作用, 本文就近年来HIF-1α、Nrf2与PD的相关性, 以及低氧环境对PD的影响进行综述。Parkinson's disease(PD)has a complex etiology and an unclear mechanism,involving genetic,environmental,and aging factors.Identifying common elements is crucial for pinpointing intervention targets.Hypoxia,which is prevalent in both natural environments and various disease states,is closely associated with the etiology of PD.It may enhance the expression and aggregation of the pathogenic proteinα-synuclein,thereby influencing the onset and progression of PD through multiple pathways.Hypoxia-induced factor-lα(HIF-1α)and nuclear factor E2 related factor 2(Nrf2)are signaling molecules that are intimately linked to oxygen regulation and play a significant role in modulating oxidative stress.The underlying mechanisms may involve reducing neuronal apoptosis,mitigating inflammatory responses,and alleviating oxidative stress.Research indicates that the activation of HIF-lαand Nrf2-related signaling pathways can provide protection to dopaminergic neurons in the substantia nigra.Consequently,this review aims to summarize the relationship between PD and HIF-1α,Nrf2,along with the implications of hypoxic environments.

关 键 词：帕金森病 缺氧 缺氧诱导因子1 

分 类 号：R742.5[医药卫生—神经病学与精神病学]