钙调磷酸酶抑制剂预防经内镜逆行胰胆管造影术后胰腺炎的研究进展  

Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with calcineurin inhibitors:research progress

作　　者：李家速 刘枫 李兆申[1] LI Jiasu;LIU Feng;LI Zhaoshen(Department of Gastroenterology,The First Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200433,China;Digestive Endoscopy Center,Shanghai Tenth People’s Hospital,Tongji University,Shanghai 200072,China)

机构地区：[1]海军军医大学(第二军医大学)第一附属医院消化内科,上海200433 [2]同济大学附属第十人民医院消化内镜中心,上海200072

出　　处：《海军军医大学学报》2024年第11期1414-1418,共5页Academic Journal of Naval Medical University

摘　　要：急性胰腺炎是经内镜逆行胰胆管造影(ERCP)术后最常见的不良事件,尽管使用了多种预防性措施,其仍是临床面临的一个棘手问题。近年来,钙调磷酸酶在胰腺炎发病机制中的作用受到关注,其特异性抑制剂为ERCP术后胰腺炎的预防提供了新的很有前景的方向。本文就近年来钙调磷酸酶及其抑制剂与ERCP术后胰腺炎预防相关的基础和临床研究进展作一综述,以期为后续研究提供更多思路。Acute pancreatitis is the most common adverse event after endoscopic retrograde cholangiopancreatography(ERCP),and it remains a challenging clinical issue despite the use of various preventive measures.In recent years,the role of calcineurin in the pathogenesis of pancreatitis has received attention,and its specific inhibitors provide a new and promising direction for preventing post-ERCP pancreatitis.This article reviews the basic and clinical progress on the relationship between calcineurin and its inhibitors and the prevention of post-ERCP pancreatitis in recent years,hoping to provide more ideas for future research.

关 键 词：经内镜逆行胰胆管造影 急性胰腺炎 钙调磷酸酶抑制剂 发病机制 预防 

分 类 号：R576[医药卫生—消化系统]