银杏叶提取物注射液联合阿托伐他汀对老年急性脑梗死患者脂质水平、炎症反应及血栓弹力图监测指标的影响  

Effect of Ginkgo biloba leaf extract injection combined with atorvastatin on lipid levels,inflammatory response and thromboelastography monitoring indices in elderly patients with acute cerebral infarction

作　　者：徐杰 袁青青 肖雷[1] XU Jie;YUAN Qing-qing;XIAO Lei(Department of Pharmacy,Eastern District,The First Affiliated Hospital of Anhui Medical University,Hefei Anhui 231600,China)

机构地区：[1]安徽医科大学第一附属医院东区药剂科,安徽合肥231600

出　　处：《临床和实验医学杂志》2024年第20期2133-2137,共5页Journal of Clinical and Experimental Medicine

基　　金：安徽省重点研究与开发计划项目(编号:202104j07020059)。

摘　　要：目的观察银杏叶提取物注射液联合阿托伐他汀对老年急性脑梗死患者脂质水平、炎症反应及血栓弹力图监测指标的影响。方法前瞻性选取2021年3月至2023年12月就诊于安徽医科大学第一附属医院东区的80例老年急性脑梗死患者作为研究对象。按照随机数字表法将入组患者分为他汀类组和联合组,每组各40例。两组均给予对症治疗,他汀类组加用阿托伐他汀治疗,联合组在他汀类组基础上给予银杏叶提取物注射液治疗。检测并比较两组患者治疗前及治疗10 d后的脂代谢[总胆固醇、甘油三酯、低密度胆固醇(LDL-C)、高密度胆固醇(HDL-C)]、趋化因子[血清趋化因子fractalkine(FKN)、CX3C趋化因子受体1(CX3CR1)]、炎症因子[白细胞介素1β(IL-1β)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]、血栓弹力图[凝血反应时间(R值)、血液凝固时间(K值)、凝血块形成曲线的最宽距离(MA值)、凝固角]及美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表(mRS)变化。结果治疗10 d后,两组总胆固醇、甘油三酯、LDL-C均较治疗前降低,HDL-C均较治疗前升高,且联合组的总胆固醇、甘油三酯、LDL-C水平分别为(3.45±0.69)、(1.77±0.54)、(2.11±0.38)mmol/L,均低于他汀类组[(3.89±0.78)、(2.03±0.59)、(2.34±0.45)mmol/L],HDL-C水平为(1.74±0.34)mmol/L,高于他汀类组[(1.57±0.33)mmol/L],差异均有统计学意义(P<0.05)。治疗10 d后,两组FKN、CX3CR1水平均较治疗前降低,联合组的FKN、CX3CR1水平分别为(1.67±0.48)、(5.17±1.64)μg/L,均低于他汀类组[(2.12±0.56)、(6.05±1.78)μg/L],差异均有统计学意义(P<0.05)。治疗10 d后,两组IL-1β、CRP、TNF-α水平均较治疗前降低,联合组的IL-1β、CRP、TNF-α水平分别为(6.07±1.22)pg/mL、(8.89±1.44)mg/L、(13.08±2.87)pg/mL,均低于他汀类组[(7.45±1.74)pg/mL、(11.56±2.05)mg/L、(17.41±3.22)pg/mL],差异均有统计学意义(P<0.05)。治疗10 d后,两组NIHSS评分、mObjective To observe the effects of Ginkgo biloba leaf extract injection combined with atorvastatin on lipid levels,inflammatory response and thromboelastography monitoring indexes in elderly patients with acute cerebral infarction.Methods Eighty elderly patients with acute cerebral infarction who were admitted to the Eastern District of the First Affiliated Hospital of Anhui Medical University from March 2021 to December 2023 were prospectively selected as the study subjects.According to the random number table method,the patients were divided into the statin group and the combined group,with 40 cases in each group.Both groups were given symptomatic treatment,the statin group was treated with atorvastatin,and the combined group was treated with Ginkgo biloba extract injection on the basis of the statin group.The lipid metabolism[total cholesterol,triglycerides,low-density cholesterol(LDL-C),high-density cholesterol(HDL-C)],chemokines[serum chemokine fractalkine(FKN),chemokine C-X3-C motif receptor 1(CX3CR1)],inflammatory factors[interleukin 1β(IL-1β),C-reactive protein(CRP),tumour necrosis factor-α(TNF-α)],thromboelastography[reaction time(R-value),blood clotting time(K-value),widest distance of the clot formation curve(MA-value),angle of coagulation],and the national institutes of health stroke scale(NIHSS),modified Rankin scale(mRS)before treatment and after 10 days of treatment were detected and compared of the two groups.Results After 10 days of treatment,the levels of total cholesterol,triglyceride and LDL-C in the two groups were lower than those before treatment,and HDL-C was higher than that before treatment,and the levels of total cholesterol,triglyceride and LDL-C in the combined group were(3.45±0.69),(1.77±0.54)and(2.11±0.38)mmol/L,respectively,which were lower than those in the statin group[(3.89±0.78),(2.03±0.59)and(2.34±0.45)mmol/L],and the level of HDL-C was(1.74±0.34)mmol/L,which was higher than that in the statin group[(1.57±0.33)mmol/L],and the differences were statistically signifi

关 键 词：银杏叶提取物注射液 阿托伐他汀 急性脑梗死 脂代谢 炎症反应 血栓弹力图 

分 类 号：R743.33[医药卫生—神经病学与精神病学]