微种植体支抗用于骨性错牙合畸形患者的疗效及对血清MMP-8、MMP-9、NO、IGF-1水平的影响  

Efficacy and serum MMP-8,MMP-9,NO and IGF-1 levels of microimplant anchorage in patients with bone malocclusion

作　　者：赵欢欢 孙洋 曹素敏[1] ZHAO Huan-huan;SUN Yang;CAO Su-min(Department of Stomatology,Cangzhou City Central Hospital,Cangzhou Hebei 061000,China)

机构地区：[1]沧州市中心医院口腔科,河北沧州061000

出　　处：《临床和实验医学杂志》2024年第20期2211-2215,共5页Journal of Clinical and Experimental Medicine

基　　金：河北省2022年度医学科学研究计划项目(编号:20220374)。

摘　　要：目的观察微种植体支抗用于骨性错牙合畸形患者的疗效及对血清基质金属蛋白酶8(MMP-8)、基质金属蛋白酶9(MMP-9)、一氧化氮(NO)、胰岛素样生长因子-1(IGF-1)水平的影响。方法前瞻性选取2022年2月至2023年12月在沧州市中心医院进行诊治的骨性错牙合畸形患者84例作为研究对象,按照随机数字表法将其分为观察组(n=42)和对照组(n=42)。观察组采用微种植体支抗治疗,对照组采用口外弓支抗治疗,统计两组治疗前和治疗6个月后的口腔结构、上下颌骨角度[上齿槽座角(SNA)、下齿槽座角(SNB)、上齿槽座点及鼻根点与下齿槽座点形成角(ANB)]、血清MMP-8、MMP-9、NO、IGF-1水平,记录两组美学满意度及并发症发生情况。结果在口腔结构方面,观察组磨牙移位为(3.21±0.84)mm,显著低于对照组[(5.32±1.11)mm],上中切牙凸距差、中切牙倾角差分别为(4.24±1.66)mm、(26.42±4.38)°,均显著高于对照组[(2.45±1.21)mm、(12.44±3.05)°],差异均有统计学意义(P<0.05)。治疗6个月后,观察组SNA、ANB分别为(72.01±2.19)°、(4.68±0.78)°,显著低于对照组[(76.49±2.21)°、(5.37±0.82)°],SNB为(78.65±2.36)°,显著高于对照组[(76.07±2.44)°],差异均有统计学意义(P<0.05)。治疗6个月后,观察组血清MMP-8、MMP-9、NO、IGF-1水平分别为(94.16±10.84)μmol/L、(74.49±9.87)pg/mL、(55.72±8.03)μmol/L、(643.85±26.32)ng/mL,显著低于对照组[(112.51±11.02)μmol/L、(86.52±10.01)pg/mL、(67.96±8.41)μmol/L、(703.36±26.96)ng/mL],差异均有统计学意义(P<0.05)。在美学满意度方面,观察组总满意度为92.86%,明显高于对照组(76.19%),差异有统计学意义(P<0.05)。在并发症方面,观察组总发生率为9.52%,明显低于对照组(30.95%),差异有统计学意义(P<0.05)。结论微种植体支抗治疗骨性错牙合畸形疗效较好,可以有效改善患者口腔结构和上下颌骨角度,调节血清MMP-8、MMP-9、NO、IGF-1水平,且美学满意度高,并发症Objective To observe the effect of microimplant anchorage on serum matrix metalloproteinase 8(MMP-8),matrix metalloproteinase 9(MMP-9),nitric oxide(NO)and insulin-like growth factor-1(IGF-1)in patients with bone malocclusion.Methods A total of 84 patients with bone malocclusion diagnosed and treated in Cangzhou City Central Hospital from February 2022 to December 2023 were prospectively selected and studied,and divided into the observation group(n=42)and the control group(n=42)according to the random number table method.The observation group was treated with microimplant anchorage,while the control group was treated with extraoral arch anchorage.The oral structure,mandibular angle[sella-nasion-A(SNA),sella-nasion-B(SNB),A point-nasion-B point(ANB)],and serum MMP-8,MMP-9,NO and IGF-1 levels of the two groups were analyzed before and 6 months after treatment.The aesthetic satisfaction and complications of the two groups were recorded.Results In terms of oral structure,the molar displacement in the observation group was(3.21±0.84)mm,which was significantly lower than that in the control group[(5.32±1.11)mm],the difference of convex distance and inclination of upper and middle incisor teeth were(4.24±1.66)mm and(26.42±4.38)°,respectively,which were significantly higher than those in the control group[(2.45±1.21)mm,(12.44±3.05)°],the differences were statistically significant(P<0.05);After 6 months of treatment,the SNA and ANB of the observation group were(72.01±2.19)°and(4.68±0.78)°,respectively,which were significantly lower than those of the control group[(76.49±2.21)°,(5.37±0.82)°]and SNB(78.65±2.36)°,respectively,which were significantly higher than those of the control group[(76.07±2.44)°],the differences were statistically significant(P<0.05).After 6 months of treatment,the serum levels of MMP-8,MMP-9,NO and IGF-1 in the observation group were(94.16±10.84)μmol/L,(74.49±9.87)pg/mL,(55.72±8.03)μmol/L and(643.85±26.32)ng/mL,respectively,which were significantly lower than those in the con

关 键 词：骨性错牙合畸形 微种植体支抗 口外弓支抗 基质金属蛋白酶8 基质金属蛋白酶9 一氧化氮 胰岛素样生长因子-1 

分 类 号：R783.5[医药卫生—口腔医学]