基于ADNI中PET/CT的阿尔茨海默病致病机制及诊断的最新研究  

Latest Research on the Pathogenesis and Diagnosis of Alzheimer's Disease Based on PET/CT from ADNI

作　　者：陈金雨 张肖南 武志芳[2] 郝新忠[2] 申佳妮 李阳[1] CHEN Jinyu;ZHANG Xiaonan;WU Zhifang;HAO Xinzhong;SHEN Jiani;LI Yang(Department of Neurology,the First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Nuclear Medicine,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院神经内科,太原030001 [2]山西医科大学第一临床医学院核医学科,太原030001

出　　处：《神经损伤与功能重建》2024年第11期669-672,共4页Neural Injury and Functional Reconstruction

基　　金：中央引导地方科技发展专项资金项目(No.YDZX20191400002563);山西省医学重点攻关专项(No.2020XM22);山西省科技厅基金(基于功能及代谢影像学技术探讨PD-MCI患者双任务下异常步态的神经机制研究,No.202203021221255)。

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)已成为中国65岁及以上人群的第四大死因,PET/CT在AD的临床诊断和致病机制研究中发挥了重要的作用,阿尔茨海默病神经影像学倡议(Alzheimer’s Disease Neuroimaging Initiative,ADNI)中的PET/CT联合数字技术为跟踪患者认知变化轨迹、提升临床诊断精度提供重要的科学支撑。本文重点综述了近3年ADNI中的PET/CT在探索AD病理进展模式及早期诊断的研究进展。Alzheimer's disease(AD)has become the fourth leading cause of death among people aged 65 and above in China.PET/CT plays a significant role in the clinical diagnosis and research on the pathogenesis of AD.The combined use of PET/CT and digital technology within the Alzheimer's Disease Neuroimaging Initiative(ADNI)provides important scientific support for tracking the trajectory of cognitive changes in patients and improving the accuracy of clinical diagnosis.This article focuses on reviewing the research progress in exploring the pathological progression patterns and early diagnosis of AD using PET/CT within ADNI over the past three years.

关 键 词：阿尔茨海默病 ADNI 正电子发射断层显像 Aβ级联假说 深度学习 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.04[医药卫生—临床医学]