自噬在急性淋巴细胞白血病中作用的研究进展  

Progress of the role of autophagy in acute lymphoblastic leukemia

作　　者：陈要灿 廖小庆 吴金燕 刘萱竹 胡晶[2] Chen Yaocan;Liao Xiaoqing;Wu Jinyan;Liu Xuanzhu;Hu Jing(College of Laboratory Medicine,Chongqing Medical University,Chongqing 400016,China;Key Laboratory of Clinical Laboratory Diagnostics,Ministry of Education Chongqing,College of Laboratory Medicine,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学检验医学院,重庆400016 [2]重庆医科大学检验医学院临床检验诊断学教育部重点实验室,重庆400016

出　　处：《白血病．淋巴瘤》2024年第9期573-576,共4页Journal of Leukemia & Lymphoma

基　　金：重庆市科技局自然科学基金面上项目(CSTB2022NSCQ-MSX0764)。

摘　　要：急性淋巴细胞白血病(ALL)作为一种主要起源于T系或B系淋巴祖细胞的恶性血液疾病,好发于儿童。随着自噬机制的逐渐揭示,自噬在ALL中的作用受到了越来越多的关注。自噬既可以作为细胞的适应性反应来刺激白血病细胞的存活,又在一些情况下抑制细胞增殖。因此,如何调控自噬的促死亡与促生存作用,减少白血病耐药已经成为研究热点。文章对自噬在ALL的作用研究进行综述。As a malignant hematological disease mainly originating from T or B lymphoid progenitor cell,acute lymphocytic leukemia(ALL)is more prevalent in children.With the gradual revelation of the autophagy mechanism,the role of autophagy in ALL has gained increasing attention.Autophagy can not only stimulate the survival of leukemia cells as an adaptive response,but also inhibit cell proliferation in some other cases.Therefore,how to regulate autophagy in promoting death or survival and reduce the drug resistance in ALL has become a hotspot.This article reviews the role of autophagy in ALL.

关 键 词：自噬 白血病 淋巴细胞 急性 治疗 细胞凋亡 耐药 

分 类 号：R733.71[医药卫生—肿瘤]