放射性小肠损伤的研究进展  

Research progress in radiation-induced small intestine injury

作　　者：王夫浩 张烨 王奇峰 杨锫[3,5] 章文成 岳金波 Wang Fuhao;Zhang Ye;Wang Qifeng;Yang Pei;Zhang Wencheng;Yue Jinbo(Department of Abdominal Radiation Oncology,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan 250117,China;Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Professional Committee of Radiation Oncology,Chinese Medicine Education Association(CMEA),Changsha 410013,China;Department of Radiation Oncology,Sichuan Cancer Hospital and Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041,China;Department of Radiation Oncology,Hunan Cancer Hospital,The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,China;Department of Radiation Oncology,Tianjin Medical University Cancer Institute&Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin's Clinical Research Center for Cancer,Tianjin 300060,China)

机构地区：[1]山东省肿瘤防治研究院(山东省肿瘤医院)腹部放疗一病区,山东第一医科大学(山东省医学科学院),济南250117 [2]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科,北京100021 [3]中国医药教育协会肿瘤放射治疗专业委员会,长沙410013 [4]四川省肿瘤医院放疗科,四川省癌症防治中心,电子科技大学附属肿瘤医院,成都610041 [5]湖南省肿瘤医院,中南大学湘雅医学院附属肿瘤医院放疗科,长沙410013 [6]天津医科大学肿瘤医院放疗科,国家恶性肿瘤临床医学研究中心,天津市恶性肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津300060

出　　处：《中华放射肿瘤学杂志》2024年第11期1016-1023,共8页Chinese Journal of Radiation Oncology

基　　金：国家自然科学基金(82272753);山东省自然科学基金(ZR2021LZL002);白求恩癌症放疗转化医学研究基金(flzh202103)。

摘　　要：手术、放疗和化疗是目前抗肿瘤治疗的主要方案。约有70%的恶性肿瘤患者需要接受放疗。然而,放射线对人体正常组织造成的损伤仍然是临床实践中难以避免的问题。在对肝癌、结直肠癌、宫颈癌、前列腺癌等腹部和盆腔肿瘤进行放疗时,由于上述器官解剖位置与小肠邻近,不可避免地会引发一定程度的肠道损伤。放疗导致的小肠损伤称为放射性小肠损伤。临床上,对于接受盆、腹部放疗的患者,放射性小肠损伤的发生率较高,这不仅影响了肿瘤患者的生存质量,而且限制了放疗效果。本文系统介绍放射性小肠损伤的研究进展。Surgery,radiotherapy and chemotherapy are currently the principal modalities for oncological treatment.Approximately 70% of patients with malignant tumors require radiotherapy.However,the damage induced by radiation on normal human tissues remains an unavoidable issue in clinical practice.When radiotherapy is applied to abdominal and pelvic tumors such as liver cancer,colorectal cancer,cervical cancer,and prostate cancer,the anatomical proximity of these organs to the small intestine inevitably leads to some degree of intestinal damage.This type of injury,induced by radiotherapy,is referred as radiation-induced small intestine injury.Clinically,a high incidence of radiation-induced small intestine injury is observed among patients receiving pelvic and abdominal radiotherapy,which not only impacts the quality of life of cancer patients,but also limits the effectiveness of the treatment.This article reviews the research progress in radiation-induced small intestine injury.

关 键 词：肿瘤 放射疗法 放射性损伤 肠道不良反应 研究进展 

分 类 号：R730.55[医药卫生—肿瘤] R818.8[医药卫生—临床医学]