放射性皮肤损伤的研究进展  

Research progress in radiation-induced skin injury

作　　者：魏金龙 赵钦 吕进财 谭紫凝 王选重 王奇峰[3,4] 岳金波 杨锫 章文成 李爽 张烨 姜新 王冰 Wei Jinlong;Zhao Qin;Lyu Jincai;Tan Zining;Wang Xuanzhong;Wang Qifeng;Yue Jinbo;Yang Pei;Zhang Wencheng;Li Shuang;Zhang Ye;Jiang Xin;Wang Bing(Department of Radiation Oncology,The First Hospital of Jilin University,Jilin Provincial Key Laboratory of Radiation Oncology&Therapy,NHC Key Laboratory of Radiobiology,School of Public Health of jilin University,Changchun 130021,China;Key Laboratory of Pathobiology,Ministry of Education,Jilin University,Changchun 130021,China;Department of Radiotherapy,Sichuan Cancer Hospital,Sichuan Cancer Prevention Center,Cancer Hospital Affiliated to University of Electronic Science and Technology of China,Chengdu 610041,China;Professional Committee of Radiation Oncology,Chinese Medicine Education Association(CMEA),Changsha 410013,China;Department of Radiotherapy,Affiliated Cancer Hospital of Shandong First Medical University,Jinan 250117,China;Department of Radiotherapy,Cancer Hospital Affiliated to Xiangya Medical College,Central South University,Hunan Cancer Hospital,Changsha 410013,China;Department of Radiotherapy,Cancer Hospital of Tianjin Medical University,National Clinical Medical Research Center of Malignant Tumor,Tianjin Clinical Medical Research Center of Malignant Tumor,Tianjin Key Laboratory of Cancer Prevention and Treatment,Tianjin 300060,China;Department of Proctology,Jilin Academy of Chinese Medicine,Changchun 130021,China;Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Radiotherapy,Jilin Cancer Hospital,Changchun 130012,China)

机构地区：[1]吉林大学第一医院放疗科,吉林省肿瘤精准放射治疗重点实验室,吉林大学公共卫生学院国家卫健委放射生物学重点实验室,长春130021 [2]吉林大学病理生物学教育部重点实验室,长春130021 [3]四川省肿瘤医院放疗科,四川省癌症防治中心,电子科技大学附属肿瘤医院,成都610041 [4]中国医药教育协会肿瘤放射治疗专业委员会,长沙410013 [5]山东第一医科大学附属肿瘤医院放疗科,济南250117 [6]湖南省肿瘤医院,中南大学湘雅医学院附属肿瘤医院放疗科,长沙410013 [7]天津医科大学肿瘤医院放疗科,国家恶性肿瘤临床医学研究中心,天津市恶性肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津300060 [8]吉林省中医药科学院肛肠科,长春130021 [9]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科,北京100021 [10]吉林省肿瘤医院放疗科,长春130012

出　　处：《中华放射肿瘤学杂志》2024年第11期1024-1032,共9页Chinese Journal of Radiation Oncology

基　　金：吉林省医疗卫生人才专项(JLSWSRCZX2023-68);吉林大学第一医院青年人才储备计划项目(JDYY-TRP-2024012);吉林省科技厅项目(20230508064RC);吉林省教育厅项目(JJKH20241337KJ)。

摘　　要：放疗是恶性肿瘤的主要治疗方法之一,但其治疗的同时会导致正常组织出现放射损伤。放射性皮肤损伤(RISI)是放疗引起的主要不良反应之一,其主要临床表现为皮炎、溃疡、糜烂以及坏死等,严重影响肿瘤放疗患者的生活质量及治疗效果,甚至影响患者总生存期。RISI的病理机制尚不明确,研究表明,炎症反应及氧化应激是引起RISI的主要原因。RISI根据发病时间的不同可以分为急性RISI和慢性RISI,根据损伤的严重程度可以制订不同的治疗策略。本文对RISI的临床表现、分级、发生机制、预防及治疗等方面的研究进展进行了全面地总结。Radiotherapy is one of the main treatment methods for malignant tumors,which can cause the radiation damage to normal tissues.Radiation-induced skin injury(RISI)is one of the main adverse reactions caused by radiotherapy.The main clinical manifestations of RISI are dermatitis,ulcer,erosion and necrosis,which seriously affect the quality of life and treatment effect of tumor radiotherapy patients,and even affect the overall survival of patients.The pathological mechanism of RISI is still unclear.Some studies have shown that inflammation and oxidative stress are the main causes of RISI.RISI can be divided into acute and chronic RISI according to the different onset time,and different treatment strategies can be formulated according to the severity of the injury.In this article,clinical manifestations,classification,pathogenesis,prevention and treatment of RISI are comprehensively summarized.

关 键 词：肿瘤 放射疗法 放射性皮肤损伤 损伤机制 

分 类 号：R730.55[医药卫生—肿瘤] R818.8[医药卫生—临床医学]