二肽基肽酶4介导的神经炎症参与神经病理性疼痛的研究进展  

Research progress of DPP4 mediated neuroinflammation in neuropathic pain

作　　者：刘燕 曾晓燕 向利 李群 张英 Liu Yan;Zeng Xiaoyan;Xiang Li;Li Qun;Zhang Ying(Department of Anesthesiology,The Affiliated Traditional Chinese Medicine Hospital,Southwest Medical University,Luzhou City,Sichuan Province 646000,China;Department of Painology,The Affiliated Traditional Chinese Medicine Hospital,Southwest Medical University,Luzhou City,Sichuan Province 646000,China)

机构地区：[1]西南医科大学附属中医医院麻醉科,泸州市646000 [2]西南医科大学附属中医医院疼痛科,泸州市646000

出　　处：《中华疼痛学杂志》2024年第4期599-605,共7页Chinese Journal Of Painology

摘　　要：神经病理性疼痛(NP)是由躯体感觉神经系统病变或疾病引起的一种慢性疼痛状态,其发病机制复杂多变,临床治疗仍面临挑战。随着对二肽基肽酶4(DPP4)进行深入的研究,DPP4及其生物活性底物通过调控炎症反应,广泛参与免疫调节、代谢和神经功能,尤其在神经炎症方面的作用逐渐得到认识,因此它有望成为NP治疗药物开发的新靶点。本文通过简要综述DPP4及其生物活性底物在NP中的作用及潜在机制,以期为NP的进一步研究和治疗提供思路。Neuropathic pain(NP)is a chronic pain state caused by lesions or diseases of the somatosensory nervous system,with complex and variable pathogenesis,and clinical treatment challenges.With in-depth studies on dipeptidyl peptidase 4(DPP4),its role and bioactive substrates are increasingly recognized,in immune modulation,metabolism,and neural functions of regulation of inflammation,especially the neuroinflammation.DPP4 is expected to become a new target for the development of drugs to treatment of NP.This article provides a brief overview of the role,the potential mechanisms and the bioactive substrates of DPP4 in NP,to offer ideas for further research and treatment of NP.

关 键 词：神经痛 二肽基肽酶IV 神经炎症 T淋巴细胞 小胶质 小神经胶质细胞 星形胶质细胞 

分 类 号：R741[医药卫生—神经病学与精神病学]