睡眠障碍与小脑调控  

Sleep disorders and cerebellar regulation

作　　者：汪彤 祝东林[1] 石静萍[1] Wang Tong;Zhu Donglin;Shi Jingping(Department of Neurology,Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属脑科医院神经内科,南京210029

出　　处：《中华行为医学与脑科学杂志》2024年第10期943-948,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：江苏省重点研发计划社会发展项目(BE2023669)。

摘　　要：小脑参与睡眠调控, 小脑功能障碍会导致睡眠紊乱, 部分睡眠障碍患者中也观察到小脑结构和功能的改变。然而对于小脑调控睡眠的确切机制尚无定论。本文综述了小脑神经元活动随睡眠觉醒周期变化的解剖基础、睡眠觉醒周期中小脑与大脑连接回路的变化以及小脑功能/结构紊乱导致的异常行为、不同睡眠障碍患者中小脑结构的异常变化, 提出小脑参与睡眠调控, 小脑功能障碍患者存在不同形式的睡眠紊乱, 而小脑结构和功能的完整性也受睡眠影响, 这提示小脑结构和功能异常与睡眠障碍之间可能存在一种互为因果的关系。基于小脑神经元具有高度的可塑性, 未来或可通过调节小脑神经元的电活动进一步探索小脑参与睡眠的电生理机制, 从而验证小脑调控改善睡眠障碍的可能性。As cerebellum is involved in sleep regulation,cerebellar dysfunction can lead to sleep disorders,and changes in cerebellar structure and function have also been observed in some patients with sleep disorders.However,the exact mechanism of cerebellum regulation of sleep is still unified.This review summarized the anatomical basis of cerebellar neuronal activity changes with sleep-wake cycle,the changes of cerebellar and brain connection circuits during sleep-wake cycle,the abnormal behaviors caused by cerebellar function/structure disorders,and the abnormal changes of cerebellar structure in patients with different sleep disorders.It is proposed that cerebellar is involved in regulating sleep,and there are different forms of sleep disorders in patients with cerebellar dysfunction.The structural and functional integrity of cerebellum are also affected by sleep,suggesting that there may be a causal relationship between cerebellar structural and functional abnormalities and sleep disorders.Based on the high plasticity of cerebellar neurons,the electrophysiological mechanisms of cerebellar involvement in sleep may be further explored by regulating the electrical activity of cerebellar neurons in the future,so as to verify the possibility of improving sleep disorders through cerebellar regulation.

关 键 词：睡眠障碍 小脑 失眠 小脑干预 

分 类 号：R740[医药卫生—神经病学与精神病学]