眼睑皮脂腺癌合并其他肿瘤4例  

Sebaceous gland carcinoma of the eyelid co-occurred with other tumors:a report of four cases

作　　者：王玉川[1] 李军[1] 郭雅图 李静 李君 林锦镛[1] Wang Yuchuan;Li Jun;Guo Yatu;Li Jing;Li Jun;Lin Jinyong(Tianjin Eye Hospital,Nankai University Affiliated Eye Hospital,Clinical College of Ophthalmology of Tianjin Medical University,Tianjin Eye Institute,Tianjin Key Laboratory of Ophthalmology and Visual Science,Tianjin 300020,China)

机构地区：[1]天津市眼科医院、南开大学附属眼科医院、天津医科大学眼科临床学院、天津市眼科研究所、天津市眼科学与视觉科学重点实验室,天津300020

出　　处：《中华眼科杂志》2024年第11期921-926,共6页Chinese Journal of Ophthalmology

基　　金：天津市医学重点学科(专科)建设项目(TJYXZDXK-016A)。

摘　　要：本文报道4例眼睑皮脂腺癌合并其他肿瘤患者,其中3例合并眼部的其他肿瘤,2例合并内脏恶性肿瘤,1例合并慢性淋巴细胞性白血病/小淋巴细胞淋巴瘤。经过免疫组织化学染色和(或)全外显子组测序,2例合并内脏恶性肿瘤的患者未被确诊为Muir-Torre综合征。此外,2例眼睑皮脂腺癌患者全外显子组测序均发现ZNF750基因突变。3例患者行眼睑肿物切除术,1例患者行眼眶内容物摘出术和眼球摘除术。随访结果显示,2例眼睑肿物和1例眼睑肿物侵犯眶内的患者未复发,1例患者因卵巢癌腹膜转移死亡。This article reported four cases of sebaceous gland carcinoma of the eyelid with other tumors.Among them,three cases were co-occurred with other ocular tumors,two cases with visceral malignancies,and one case with chronic lymphocytic leukemia/small lymphocytic lymphoma.Immunohistochemistry and/or whole-exome sequencing confirmed that the two cases with visceral malignancies did not meet the criteria for Muir-Torre syndrome.Additionally,whole-exome sequencing was performed on two cases of sebaceous gland carcinoma of the eyelid,both revealing mutations in the ZNF750 gene.Surgical interventions included excision of the eyelid tumors in three cases and enucleation of orbital tissues and eye removal in one case.Follow-up results showed no recurrence in two cases with eyelid tumors and one case with orbital invasion,while one patient died due to peritoneal metastasis from ovarian cancer.

关 键 词：眼睑肿瘤 皮脂腺肿瘤 肿瘤浸润 肿瘤转移 全外显子组测序 DNA错配修复 

分 类 号：R739.7[医药卫生—肿瘤]