神经生长因子局部注射联合甲硝唑片在根管治疗后牙龈肿痛患者中的应用效果  

Effect of Nerve Growth Factor Local Injection Combined with Metronidazole Tablets in Patients with Gum Swelling and Pain after Root Canal Treatment

作　　者：牟琳娜 MOU Linna(Department of Stomatology,Lanshan District People's Hospital,Linyi 276000,China)

机构地区：[1]临沂市兰山区人民医院口腔科,山东临沂276000

出　　处：《反射疗法与康复医学》2024年第17期130-133,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的观察神经生长因子局部注射联合甲硝唑片在根管治疗后牙龈肿痛患者中的应用效果。方法选取临沂市兰山区人民医院2021年5月—2023年11月收治的86例根管治疗后牙龈肿痛患者为研究对象。按随机数字表法将其分为对照组与观察组,各43例。对照组给予甲硝唑片治疗,观察组给予神经生长因子局部注射联合甲硝唑片治疗,10 d为1个疗程,两组均持续治疗2个疗程。对比两组的临床症状评分、牙周指标、龈沟液炎症因子、不良反应。结果治疗前,两组临床症状评分、牙周指标、龈沟液炎症因子水平对比,组间差异无统计学意义(P>0.05);治疗后,观察组牙周软组织肿胀、牙根周疼痛、牙齿松动症状评分分别为(0.68±0.33)分、(0.48±0.22)分、(0.49±0.21)分,均低于对照组的(1.05±0.43)分、(0.94±0.31)分、(0.87±0.32)分,组间差异有统计学意义(P<0.05);治疗后,观察组牙周袋深度(1.73±0.78)mm,浅于对照组的(2.80±0.64)mm,牙龈沟出血指数(0.80±0.36)分,低于对照组的(1.25±0.44)分,组间差异有统计学意义(P<0.05);治疗后,观察组龈沟液白细胞介素-6、C反应蛋白水平均低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论神经生长因子局部注射联合甲硝唑片治疗根管治疗后牙龈肿痛,能够减轻牙龈炎症,改善临床症状及牙周健康,且安全性高。Objective To observe the effect of nerve growth factor local injection combined with metronidazole tablets in patients with gum swelling and pain after root canal treatment.Methods A total of 86 patients with gingival swelling and pain after root canal treatment admitted to Lanshan District People's Hospital of Linyi City from May 2021 to November 2023 were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 43 cases in each group.The control group was treated with metronidazole tablets,and the observation group was treated with nerve growth factor local injection combined with metronidazole tablets,10 days as a course of treatment,both groups received continuous treatment for 2 courses.The clinical symptom scores,periodontal indexes,inflammatory factors in gingival crevicular fluid,and adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in clinical symptom scores,periodontal indexes,and inflam-matory factors in gingival crevicular fluid between the two groups(P>0.05).After treatment,the symptom scores of periodontal soft tissue swelling,periroot pain and tooth loosening in the observation group were(0.68±0.33)points,(0.48±0.22)points and(0.49±0.21)points,respectively,which were lower than(1.05±0.43)points,(0.94±0.31)points and(0.87±0.32)points in the control group.The difference between the two groups was statistically significant(P<0.05).After treatment,the depth of periodontal pocket in the observation group was(1.73±0.78)mm,which was shallower than(2.80±0.64)mm in the control group,and the sulcus bleeding index was(0.80±0.36)points,which was lower than(1.25±0.44)points in the control group,and the differences between the two groups were statistically significant(P<0.05).After treatment,the levels of interleukin-6 and C-reactive protein in gingival crevicular fluid of the observation group were lower than those of the control group,and the dif

关 键 词：牙龈肿痛 根管治疗 神经生长因子 甲硝唑片 临床症状 炎症 牙周健康 

分 类 号：R781.3[医药卫生—口腔医学]