雷珠单抗球内注射联合眼底激光治疗视网膜分支静脉阻塞继发黄斑水肿的疗效分析  

Efficacy analysis of intraocular injection of leizumab combined with fundus laser in the treatment of macular edema secondary to branch retinal vein occlusion

作　　者：马德柱 MA De-zhu(Bijie Aier Eye Hospital,Bijie 551799,China)

机构地区：[1]毕节爱尔眼科医院,551799

出　　处：《中国实用医药》2024年第21期112-114,共3页China Practical Medicine

摘　　要：目的 探讨眼底激光、雷珠单抗球内注射联合治疗视网膜分支静脉阻塞(BRVO)继发黄斑水肿(ME)患者的临床效果。方法 选择88例BRVO继发ME患者作为研究对象,按照信封法随机分为研究组和对照组,每组44例。研究组予以雷珠单抗球内注射、眼底激光联合治疗,对照组行眼底激光治疗。比较两组最佳矫正视力、黄斑中心凹厚度及不良反应发生情况。结果 治疗前,两组最佳矫正视力、黄斑中心凹厚度比较无统计学意义(P>0.05);治疗6个月,两组最佳矫正视力、黄斑中心凹厚度均小于治疗前,且研究组最佳矫正视力(0.30±0.08)、黄斑中心凹厚度(288.98±24.39)μm均小于对照组的(0.39±0.10)、(347.86±35.27)μm(P<0.05)。两组一过性眼压升高、玻璃体出血、球结膜出血、眼内炎发生率比较均无统计学意义(P>0.05)。结论 联合应用眼底激光、雷珠单抗球内注射治疗BRVO继发ME,可有效改善患者最佳矫正视力及黄斑中心凹厚度,且安全性较为理想。Objective To explore the clinical effect of intraocular injection of leizumab combined with fundus laser in the treatment of macular edema(ME)secondary to branch retinal vein occlusion(BRVO).Methods A total of 88 patients with ME secondary to BRVO were selected as the subjects of this study and divided into a study group and a control group according to the envelope method,with 44 cases in each group.The study group received intraocular injection of leizumab and fundus laser combined treatment,while the control group was treated with fundus laser.The best corrected visual acuity,macular fovea thickness,occurrence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistical significance in the best corrected visual acuity and the macular fovea thickness between the two groups(P>0.05).After 6 months of treatment,the best corrected visual acuity and the macular fovea thickness in both groups were less than those before treatment;the study group had best corrected visual acuity of(0.30±0.08)and macular fovea thickness of(288.98±24.39)μm,which were lower than(0.39±0.10)and(347.86±35.27)μm in the control group(P<0.05).There was no statistical significance in the incidence of transient intraocular elevation,vitreous hemorrhage,bulbar conjunctival hemorrhage and endophthalmitis between the two groups(P>0.05).Conclusion The combination of intraocular injection of leizumab and fundus laser is effective and safe in the treatment of ME secondary to BRVO,and can effectively improve the best corrected visual acuity and the macular fovea thickness of patients.

关 键 词：视网膜分支静脉阻塞 黄斑水肿 雷珠单抗 眼底激光 最佳矫正视力 黄斑中心凹 

分 类 号：R774.5[医药卫生—眼科]