儿科重症监护病房中惊厥性癫痫持续状态患儿短期预后不良的高危因素Logistic回归分析  

Logistic Regression Analysis of High-Risk Factors for Short-Term Poor Prognosis in Children with Convulsive Status Epilepticus in Pediatric Intensive Care Units

作　　者：毛江东 MAO Jiangdong(Department of Pediatric Critical Care Medicine,Shanghai Children's Medical Center Guizhou Hospital,Guiyang 550081,China)

机构地区：[1]上海儿童医学中心贵州医院儿童重症医学科,贵州贵阳550081

出　　处：《反射疗法与康复医学》2024年第12期77-80,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的分析儿科重症监护病房(PICU)中惊厥性癫痫持续状态(CSE)患儿短期预后不良的影响因素。方法回顾性分析2022年6月—2024年1月上海儿童医学中心贵州医院PICU收治的83例CSE患儿的病历资料。收集研究对象的一般资料,判定患儿是否发生短期预后不良,并将发生短期预后不良的患儿纳入预后不良组(n=23),将未发生短期预后不良的患儿纳入预后良好组(n=60)。结果83例CSE患儿中有23例出现短期预后不良,发生率为27.71%(23/83),未发生60例,未发生率为72.29%(60/83)。单因素分析显示,性别、惊厥史、发作类型、意识障碍、药物治疗与CSE患儿短期预后不良的发生无关,组间差异无统计学意义(P>0.05);年龄、发作持续时间、生长发育情况、PICU住院时间与CSE患儿短期预后不良的发生有关,组间差异有统计学意义(P<0.05)。将发生短期预后不良影响因素作为因变量,即年龄≤2岁、发作持续时间≥60 min、生长发育迟缓、PICU住院时间≥3 d作为可能导致短期预后不良发生的因素进行赋值,多因素分析显示,年龄≤2岁、发作持续时间≥60 min、生长发育迟缓、PICU住院时间≥3 d均是导致CSE患儿发生短期不良预后的独立影响因素,组间差异有统计学意义(P<0.05)。结论儿童重症监护病房中CSE患儿发生短期预后不良的因素较多,临床应制订相应的防护策略,以减少短期预后不良的发生,改善疾病预后。Objective Analyzing the influencing factors of short-term poor prognosis in children with convulsive status epilepticus(CSE)in pediatric intensive care units(PICU).Methods Retrospective analysis of medical records of 83 children with CSE admitted to the PICU of Shanghai Children's Medical Center Guizhou Hospital from June 2022 to January 2024.Collect general information of the research subjects,determine whether the children have short-term poor prognosis,and include children with short-term poor prognosis in the poor prognosis group(n=23),and include children without short-term poor prognosis in the good prognosis group(n=60).Results Among 83 cases of CSE,23 cases had poor short-term prognosis,with an incidence rate of 27.71%(23/83),while 60 cases did not occur,with an incidence rate of 72.29%(60/83).Univariate analysis showed that gender,seizure history,seizure type,consciousness disorders,and medication treatment were not associated with the occurrence of poor short-term prognosis in children with CSE,there were no statistically significant differences between the two groups(P>0.05);Age,duration of seizures,growth and development status,and PICU hospitalization time are related to the occurrence of poor short-term prognosis in children with CSE,the differences between the groups were statistically significant(P<0.05).Assign values to factors that may lead to short-term poor prognosis,such as age≤2 years,duration of onset≥60 minutes,growth and development delay,and PICU hospitalization time≥3 days,as dependent variables,multivariate analysis showed that age≤2 years,duration of onset≥60 minutes,growth and development delay,and PICU hospitalization time≥3 days were independent influencing factors for short-term poor prognosis in children with CSE,the differences between the groups were statistically significant(P<0.05).Conclusion There are many factors that can cause short-term poor prognosis in children with CSE in the intensive care unit.Corresponding protective strategies should be developed clinic

关 键 词：惊厥性癫痫持续状态 重症监护病房 短期预后不良 影响因素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]