马来酸曲美布汀联合谷维素治疗肠功能紊乱的疗效分析  

Efficacy Analysis of Trimebutine Maleate Combined with Oryzanol in the Treatment of Intestinal Dysfunction

作　　者：房贤村 刘云霞[2] 张广林[2] FANG Xiancun;LIU Yunxia;ZHANG Guanglin(Department of General Surgery,Shouguang People's Hospital,Weifang 262700,Shandong,China;Department of Gastroenterology,Shouguang People's Hospital,Weifang 262700,Shandong,China)

机构地区：[1]寿光市人民医院普外科,山东潍坊262700 [2]寿光市人民医院消化内科,山东潍坊262700

出　　处：《系统医学》2024年第19期122-124,128,共4页Systems Medicine

摘　　要：目的 分析马来酸曲美布汀联合谷维素治疗肠功能紊乱的疗效。方法 非随机选取2022年8月—2023年9月寿光市人民医院收治的70例肠功能紊乱患者为研究对象,并根据治疗方法不同分为常规组与研究组,各35例。将马来酸曲美布汀应用于常规组,研究组以常规组为基础,给予谷维素治疗,分析对比两组治疗效果、肠道改善情况、胃肠功能指标、炎症因子水平。结果 研究组治疗总有效率为97.14%(34/35),高于常规组的82.86%(29/35),差异有统计学意义(χ^(2)=3.968,P<0.05)。研究组腹痛次数、大便次数、便血次数、肠鸣音次数均少于常规组,差异有统计学意义(P均<0.05)。治疗后研究组血清胃泌素和促胃动素水平均高于常规组,差异有统计学意义(P均<0.05)。治疗后研究组炎症因子水平均低于常规组,差异有统计学意义(P均<0.05)。结论 肠功能紊乱患者采取马来酸曲美布汀联合谷维素治疗可提高治疗有效率,改善胃肠功能、减轻炎症反应。Objective To analyze the therapeutic effect of trimebutin maleate combined with glutamate on intestinal dysfunction.Methods A total of seventy patients with intestinal dysfunction admitted to Shouguang People's Hospital from August 2022 to September 2023 were non-randomly selected as the study objects,and were divided into conven-tional group and research group according to different treatment methods,with thirty-five cases in each group.Trime-butin maleate was applied to the conventional group,and the research group was treated with glutamate on the basis of the conventional group,and the therapeutic effect,intestinal improvement,gastrointestinal function index and inflam-matory factor level of the two groups were analyzed and compared.Results The total effective rate of the study group was 97.14%(34/35),which was higher than 82.86%(29/35)of the conventional group,the difference was statistically significant(χ^(2)=3.968,P<0.05).The frequency of abdominal pain,stool,blood stool and bowel sound in the study group were lower than those in the conventional group,the differences were statistically significant(all P<0.05).After treatment,the levels of serum gastrin and motilin in the study group were higher than those in the conventional group,and the differences were statistically significant(both P<0.05).After treatment,the levels of inflammatory factors in the study group were lower than those in the conventional group,and the differences were statistically significant(all P<0.05).Conclusion The combination of trimebutin maleate and glutamate in the treatment of patients with intesti-nal dysfunction can improve the therapeutic efficiency,improve gastrointestinal function and reduce inflammatory re-sponse.

关 键 词：肠功能紊乱 马来酸曲美布汀 谷维素 

分 类 号：R574[医药卫生—消化系统]