能谱增强CT联合血清miR-92b-3p、AFF3在胃癌淋巴结转移及预后中的预测价值  

Predictive Value of Spectral-enhanced CT Combined with Serum miR-92b-3p and AFF3 for Lymph Node Metastasis and Prognosis of Gastric Cancer Patients

作　　者：李嵘 许园晨 李琰 LI Rong;XU Yuan-chen;LI Yan(Department of Medical Imaging,The First Affiliated Hospital of Henan University,Kaifeng 475000,Henan Province,China;Department of Thoracic Surgery,The First Affiliated Hospital of Henan University,Kaifeng 475000,Henan Province,China)

机构地区：[1]河南大学第一附属医院医学影像科 [2]河南大学第一附属医院胸外科,河南开封475000

出　　处：《中国CT和MRI杂志》2024年第11期131-134,共4页Chinese Journal of CT and MRI

基　　金：开封市科学技术局资助项目(2207008)。

摘　　要：目的探究能谱增强CT联合血清miR-92b3p、AFF3在胃癌患者淋巴结转移及预后中的预测价值。方法选取2021年4月至2022年4月来我院治疗的120例确诊的胃癌患者为研究对象,根据是否发生淋巴结转移分为转移组(48例)和未转移组(72例),根据预后生存情况分为死亡组(43例)和生存组(77例)。受试者工作特征(ROC)曲线分析血清miR92b-3p、AFF3水平对胃癌患者发生淋巴结转移及预后的预测价值;四格表法分析能谱增强CT联合血清miR-92b-3p、AFF3水平对胃癌患者发生淋巴结转移及预后的预测价值。结果转移组血清miR92b-3p显著高于未转移组(P<0.05),AFF3水平显著低于未转移组(P<0.05);死亡组血清miR-92b-3p显著高于生存组(P<0.05),AFF3水平显著低于生存组(P<0.05);三者联合预测胃癌患者发生淋巴结转移的敏感性为95.83%,特异性为70.83%,准确率为80.83%。三者联合预测的敏感性显著高于三者单独预测(P<0.05),特异性显著低于miR-92b-3p单独预测(P<0.05),准确率显著高于能谱增强CT单独预测(P<0.05);三者联合预测胃癌患者发生死亡的敏感性为69.77%,特异性为88.31%,准确率为81.67%。三者联合预测的敏感性显著低于能谱增强CT单独预测(P<0.05),特异性显著高于miR-92b3p、AFF3、能谱增强CT单独预测(P<0.05),准确率显著高于miR-92b-3p、AFF3单独预测(P<0.05)。结论胃癌淋巴结转移及死亡患者血清miR-92b-3p水平上调,AFF3水平下调,能谱增强CT联合血清miR92b-3p,AFF3对胃癌患者发生淋巴结转移及预后有较高的预测效能。Objective To explore the predictive value of spectral-enhanced CT combined with serum miR-92b-3p and AFF3 in lymph node metastasis and prognosis of gastric cancer patients.Methods From April 2021 to April 2022,120 confirmed gastric cancer patients treated in our hospital were collected as subjects.They were separated into a metastatic group(48 cases)and a non metastatic group(72 cases)based on whether lymph node metastasis occurred.They were also separated into a death group(43 cases)and a survival group(77 cases)based on their prognosis and survival status.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum miR-92b-3p and AFF3 levels for lymph node metastasis and prognosis in gastric cancer patients;four grid table method was applied to analyze the predictive value of spectral-enhanced CT combined with serum miR-92b-3p and AFF3 levels for lymph node metastasis and prognosis in gastric cancer patients.Results The serum miR92b-3p level in the metastatic group was greatly higher than that in the non metastatic group(P<0.05),and the level of AFF3 was greatly lower than that in the non metastatic group(P<0.05);the serum miR-92b-3p level in the death group was greatly higher than that in the survival group(P<0.05),and the level of AFF3 was greatly lower than that in the survival group(P<0.05);the sensitivity,specificity,and accuracy of the combined prediction of lymph node metastasis in gastric cancer patients were 95.83%,70.83%,and 80.83%,respectively.The sensitivity of the combined prediction of the three was greatly higher than that of the single prediction of the three(P<0.05),the specificity was greatly lower than that of the single prediction of miR-92b-3p(P<0.05),and the accuracy was greatly higher than that of the single prediction of spectral-enhanced CT(P<0.05);the sensitivity,specificity,and accuracy of the combined prediction of mortality in gastric cancer patients were 69.77%,88.31%,and 81.67%,respectively.The sensitivity of the combined prediction of the three

关 键 词：胃癌 miR-92b-3p AFF3 能谱增强CT 淋巴结转移 预后 

分 类 号：R573[医药卫生—消化系统] R44[医药卫生—内科学]