鼻咽癌住院病人营养状况分析及对生活质量的影响  

Analysis of nutritional status of nasopharyngeal carcinoma patients and its impact on quality of life

作　　者：周凯 苟小霞 马虎 何国平 田昕 徐晖 冯碧 ZHOU Kai;GOU Xiao-xia;MA Hu;HE Guo-ping;TIAN Xin;XU Hui;FENG Bi(Department of Oncology,The Second Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,China)

机构地区：[1]遵义医科大学第二附属医院肿瘤科,贵州遵义563000

出　　处：《肠外与肠内营养》2024年第5期280-287,共8页Parenteral & Enteral Nutrition

基　　金：贵州省抗癌协会科技计划项目(抗协科技006[2023]);贵州省科技计划项目(黔科合基础-ZK [2024]一般346);贵州省科技计划项目(黔科合成果-LC[2024]061);北京医卫健康公益基金(编号:YWJKJJHKYJJ-F3117D)。

摘　　要：目的:探讨鼻咽癌住院病人营养状况与生活质量的相关性并分析影响营养状况的因素,为临床营养支持治疗提供依据。方法:本研究通过回顾性收集遵义医科大学附属医院头颈肿瘤科2014年至2019年符合入排标准的鼻咽癌住院病人数据;运用NRS 2002量表进行营养风险筛查,PG-SGA量表进行营养状况评估,以及EORTCQLQ-C30 V3.0量表评估生活质量。进一步探讨营养状况和生活质量之间的相关性,以及影响营养状况的因素。结果:共收集216例病人,其中男性病人168例(77.78%);平均年龄(50.50±10.58)岁;26.85%存在营养风险(NRS 2002≥3分);28.70%病人中度营养不良(PG-SGA 4~8分),23.15%病人重度营养不良(PG-SGA≥9分)。不同营养状况病人的多项体格检查(如体质量、体质指数、上臂中点肌肉周径等)、血液生化指标(如前白蛋白、中性粒细胞、尿素氮等)组间具有差异(P <0.05)。重度营养不良(PG-SGA≥9分)单因素分析显示,年龄≥65岁是发生重度营养不良的危险因素(OR值:3.429,95%CI:1.467~8.014,P=0.004),而高学历(高中及以上)是保护因素(OR值:0.027,95%CI:0.011~0.064,P <0.001)。鼻咽癌病人营养状况越差,生活质量越低。结论:鼻咽癌病人营养不良发生率高;病人营养状况越差,生活质量越低下;建议鼻咽癌病人在入院后进行常规营养诊断和治疗,以改善临床结局。Objective:To investigate the correlation between nutritional status and quality of life in inpatients with nasopharyngeal carcinoma and to analyze the factors affecting nutritional status,so as to provide evidence for clinical nutritional support treatment.Methods:In this study,we retrospectively collected data from patients with nasopharyngeal carcinoma who met the inclusion and exclusion criteria in the Head and Neck Oncology Department of Zunyi Medical University Affiliated Hospital from 2014 to 2019.The NRS 2002 scale was used for nutritional risk screening,the PG-SGA scale for nutritional status assessment and the EORTCQLQ-C30 V3.0 scale for quality of life assessment.To further explore the correlation between nutritional status and quality of life,as well as the factors affecting nutritional status.Results:A total of 216 patients were collected,including 168 male(77.78%);average age(50.5±10.58)years;26.85%were at nutritional risk(NRS 2002 score≥3);28.70%were moderate malnutrition(PG-SGA score 4-8),and 23.15%were severe malnutrition(PG-SGA score≥9).There were significant differences in several physical examinations(such as body weight,body mass index,muscle circumference at the midpoint of the upper arm,etc.)and blood biochemical indexes(such as prealbumin,neutrophils,urea nitrogen,etc.)of patients with different nutritional status were differed between groups(P<0.05).Univariate analysis showed that age≥65 years was a risk factor for the development of severe malnutrition(OR:3.429,95%CI:1.467 to 8.014,P=0.004),whereas a high level of education(senior high school and above)was a protective factor(OR:0.027,95%CI:0.011 to 0.064,P=0.000).The poorer the nutritional status of nasopharyngeal carcinoma patients,the lower the quality of life.Conclusion:Nasopharyngeal carcinoma patients have a high incidence of malnutrition;the poorer the nutritional status of the patient,the lower the quality of life;routine nutritional diagnosis and treatment of nasopharyngeal carcinoma patients after admission to the hospita

关 键 词：鼻咽癌 营养状况 PG-SGA 生活质量 营养不良 

分 类 号：R739.63[医药卫生—肿瘤]