基质金属蛋白酶-13在多发性骨髓瘤中的作用研究  

The Role of Matrix Metalloproteinase-13 in Multiple Myeloma

作　　者：贾海英[1] 郭淑丽[1] 余亮 黄国虹[1] 王昌敏[1] JIA Hai-Ying;GUO Shu-Li;YU Liang;HUANG Guo-Hong;WANG Chang-Min(Clinical Laboratory Center,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,Xinjiang Uygur Autonomous Region,China;Institute of Pediatrics,Children's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Hospital of Beijing Children′sHospital,Urumqi 830000,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]新疆维吾尔自治区人民医院临床检验中心,新疆乌鲁木齐830001 [2]北京儿童医院新疆医院,新疆维吾尔自治区儿童医院儿科研究所,新疆乌鲁木齐830000

出　　处：《中国实验血液学杂志》2024年第6期1776-1780,共5页Journal of Experimental Hematology

基　　金：新疆维吾尔自治区自然科学基金项目(2019D01C103)。

摘　　要：目的:探讨基质金属蛋白酶-13(MMP-13)在多发性骨髓瘤(MM)疾病发生发展及病情判断、预后评估等方面的作用。方法:收集MM患者57例、正常对照人群45例,采用实时荧光定量PCR检测研究对象MMP-13基因mRNA表达水平,比较MM患者组和正常对照组MMP-13 mRNA表达水平的差异,分析MMP-13与MM骨病及其严重程度、ISS分期、DS分期及治疗效果的关系。结果:MM患者MMP-13mRNA表达水平较正常对照组显著升高(P<0.05);有骨病的MM患者较无骨病的患者MMP-13 mRNA明显升高,且骨病越严重升高越明显(P<0.05);ISS分期及DS分期Ⅰ期与Ⅲ期患者之间MMP-13 mRNA差异也有统计学意义(P<0.05);患者治疗后较治疗前MMP-13明显下降(P<0.05)。结论:MMP-13基因mRNA表达水平与MM发生发展相关,其表达水平在病情判断、预后评估等方面具有一定的指导意义。Objective:To investigate the role of matrix metalloproteinase-13(MMP-13)in the development,diagnosis and prognosis of multiple myeloma(MM).Methods:Blood samples of 57 MM patients and 45 normal controls were collected,and real-time PCR was performed to detect the MMP-13 mRNA expression level in the study subjects,and the difference of MMP-13 mRNA level between MM patients and normal controls was compared.The correlations of MMP-13 with MM bone disease and its severity,ISS stage,DS stage,and treatment efficacy were analyzed.Results:The MMP-13 mRNA in patients with MM was significantly higher than that in normal controls(P<0.05).The MMP-13 mRNA in MM patients with bone disease was significantly higher than that in patients without bone disease,and the more severe the bone disease,the more obvious the increase in MMP-13 mRNA(P<0.05).The MMP-13 gene expression level was also significantly different between ISS and DS stageⅠand stageⅢpatients(P<0.05),and the MMP-13 mRNA level was significantly decreased after treatment(P<0.05).Conclusion:The MMP-13 mRNA expression level is related to the occurrence and development of MM,and it has certain guiding significance in disease diagnosis and prognosis evaluation.

关 键 词：MMP-13 多发性骨髓瘤 骨髓瘤骨病 分期 疗效 

分 类 号：R733.3[医药卫生—肿瘤]