罂粟碱注射液结合脉络宁、阿司匹林对急性脑梗死疗效与神经功能缺损评分的影响  

Effect of Papaverine Injection Combined with Mailuoning and Aspirin on Efficacy and Neurological Deficit Score in Patients with Acute Cerebral Infarction

作　　者：褚青合 王俊 陈煦 徐鹏冲 王艳 CHU Qing-he;WANG Jun;CHEN Xu;XU Peng-chong;WANG Yan(Department of Internal Medicine,Nanyang ZhangZhongjing Hospital,Nanyang 473000,Henan Province,China;Department of Emergency,Nanyang Zhangzhongjing Hospital,Nanyang 473000,Henan Province,China;Department of Imaging,Affiliated Hospital of Traditional Chinese Medicine,Nanyang Medical College,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳张仲景医院内科,河南南阳473000 [2]南阳张仲景医院急诊科,河南南阳473000 [3]南阳医学高等专科学校附属中医院影像科,河南南阳473000

出　　处：《罕少疾病杂志》2024年第11期22-24,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的分析罂粟碱注射液结合脉络宁、阿司匹林对急性脑梗死患者疗效与神经功能缺损评分的影响。方法选取我院2020年12月至2022年12月期间收治的80例急性脑梗死患者作为探讨对象,以抽签法分为对照组与观察组,每组40例。对照组使用脉络宁、阿司匹林治疗,观察组在此基础上另给予罂粟碱注射液,对比两组神经功能改善、脑血流动力学、疗效、凝血功能指标、不良反应。结果治疗后观察组神经功能评分低于对照组(P<0.05);治疗后观察组脑血流动力高于对照组(P<0.05);观察组治疗总有效率为92.50%,高于对照组75.00%(P<0.05);治疗后观察组D-D(D-二聚体)低于对照组,PT(凝血酶原血)、TT(凝血酶时间)、APTT(活化凝血酶活化时间)均高于对照组(P<0.05);观察组不良反应发生率为12.50%,高于对照组7.50%,但(P>0.05)。结论联合用药能够显著改善急性脑梗死患者的神经功能,对脑血流动力及凝血功能具有一定影响,疗效较好且安全性尚可,临床建议使用。Objective To analyze the effects of papaverine injection combined with Mailuolin and aspirin on the efficacy and neurological deficit score of patients with acute cerebral infarction.Methods A total of 80 patients with acute cerebral infarction admitted to our hospital from December 2020 to December 2022 were selected as research objects and divided into control group and observation group by drawing lots,with 40 cases in each group.Results After treatment,the neurological function score of observation group was lower than that of control group(P<0.05).After treatment,cerebral blood flow dynamics in observation group was higher than that in control group(P<0.05).The total effective rate of observation group was 92.50%,which was higher than that of control group 75.00%(P<0.05).After treatment,D-D(D-dimer)in observation group was lower than that in control group,and PT(prothrombin blood),TT(thrombin activation time)and APTT(activated thrombin activation time)were higher than those in control group(P<0.05).The incidence of adverse reactions in observation group was 12.50%,which was higher than that in control group(7.50%,P>0.05).Conclusion Combined medication can significantly improve the neurological function of patients with acute cerebral infarction,and has certain effects on cerebral blood flow dynamics and coagulation function.The efficacy is good and the safety is reasonable,so it is recommended for clinical use.

关 键 词：罂粟碱注射液 脉络宁 阿司匹林 急性脑梗死 神经功能缺损 

分 类 号：R743.33[医药卫生—神经病学与精神病学]