老年癫痫经丙戊酸联合拉莫三嗪治疗后认知功能、心理状态变化分析  

Analysis of Cognitive Function and Psychological State Changes in Elderly Patients with Epilepsy after Treatment with Valproic Acid Combined with Lamotrigine

作　　者：张艳丽 王亚兵 常留军 ZHANG Yan-li;WANG Ya-bing;CHANG Liu-jun(Department of Rehabilitation Physiotherapy,The 989th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China,Pingdingshan 467000,Henan Province,China;Department of General Medicine,The 989th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China,Pingdingshan 467000,Henan Province,China;Department of Neuroendocrine,The 989th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China,Pingdingshan 467000,Henan Province,China)

机构地区：[1]中国人民解放军联勤保障部队第九八九医院康复理疗科,河南平顶山467000 [2]中国人民解放军联勤保障部队第九八九医院全科医学科,河南平顶山467000 [3]中国人民解放军联勤保障部队第九八九医院神经内分泌科,河南平顶山467000

出　　处：《罕少疾病杂志》2024年第11期25-27,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的分析老年癫痫患者经丙戊酸联合拉莫三嗪治疗后认知功能、心理状态变化。方法选取76例中国人民解放军联勤保障部队第九八九医院收治的老年癫痫患者进行研究,于2021年7月至2023年7月完成选例,根据随机数字表法将其分为两组,A组(38例,采用丙戊酸治疗)、B组(38例,采用丙戊酸+拉莫三嗪治疗。两组均治疗6个月。比较两组各项临床指标。结果A组、B组进行比较,后者临床总有效率更高(治疗后);A组、B组比较,两组治疗后血清NSE水平、HAMA评分、HAMD评分均降低(相较于治疗前),而后者变化更明显;血清NGF、BDNF水平、MoCA评分均升高(相较于治疗前),而后者变化更明显,有差异(P<0.05)。A组、B组比较,两组不良反应总发生率无差异(P>0.05)。结论丙戊酸联合拉莫三嗪治疗老年癫痫效果显著,可有效改善认知功能和心理状态,促进神经功能恢复,同时安全性良好。Objective To analyze the changes of cognitive function and psychological state in elderly patients with epilepsy after treatment with valproic acid combined with lamotrigine.Methods A total of 76 elderly patients with epilepsy admitted to No.989th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army hospital were selected for the study.The selection was completed from July 2021 to July 2023,and they were divided into two groups according to the random number table method.Group A(38 cases,treated with valproic acid)and group B(38 cases,treated with valproic acid+lamotrigine).Both groups were treated for 6 months.The clinical indexes of the two groups were compared.Results Compared with group A and group B,the total clinical effective rate of the latter was higher(after treatment);compared with group A and group B,the serum NSE level,HAMA score and HAMD score of the two groups decreased after treatment(compared with before treatment),while the latter changed more significantly;serum NGF,BDNF levels and MoCA scores increased(compared with before treatment),while the latter changed more significantly,with differences(P<0.05).There was no difference in the total incidence of adverse reactions between group A and group B(P>0.05).Conclusion Valproic acid combined with lamotrigine in the treatment of senile epilepsy have a significant effect,which can effectively improve cognitive function and psychological state,promote the recovery of neurological function,and have high safety.

关 键 词：癫痫 丙戊酸 拉莫三嗪 认知功能 心理状态 

分 类 号：R742.1[医药卫生—神经病学与精神病学]