QCM传感器在生物医学检测中的应用研究进展  

Research progress of QCM sensors in biomedical detection

作　　者：郑学璇 黄思淇 陈学梅 惠原 王芬 郝燕 周斌 Zheng Xue-xuan;Huang Si-qi;Chen Xue-mei;Hui Yuan;Wang Fen;Hao Yan;Zhou Bin(Department of Immunology,Zhuhai Campus of Zunyi Medical University,Zhuhai 519041,China)

机构地区：[1]遵义医科大学珠海校区免疫学教研室,广东珠海519041

出　　处：《化学传感器》2024年第1期40-48,共9页Chemical Sensors

基　　金：贵州省科技计划项目(黔科合基础-ZK[2021]一般484、黔科合基础-ZK[2022]一般590、黔科合平台人才-[2018]5772-019);贵州省卫健委科技基金(gzwkj2022-176);贵州省教育厅青年科技人才成长项目(黔教合KY[2022]282)。

摘　　要：现代医学在治疗技术和药物研发不断提升的同时,也越来越依赖于医学检测技术的进步。石英晶体微天平(quartz crystal microbalance,QCM)是基于石英晶体压电效应的一种新型高灵敏的纳克级质量型传感技术,具有实时监测、高灵敏度、免标记等优势,近年在生物医学检测领域中广泛应用。该文概述了近年来QCM传感器的构建及其在核酸、蛋白质、癌细胞和微生物检测中的应用研究进展,并对其未来的发展方向进行探讨。Modern medicine is increasingly dependent on the advancement of medical testing technology while therapeutic technology and drug development are constantly improving.Quartz crystal microbalance(QCM)is a novel and highly sensitive nanogram-scale mass-based sensing technology based on the piezoelectric effect of quartz crystals,which has the advantages of real-time monitoring,high sensitivity,and labeling-free,and has been widely used in the field of biomedical detection in recent years.Herein,we outline the research progress of the construction of QCM sensors and their applications in nucleic acid,protein,cancer cell and microorganism detection in recent years,and discusses its future development direction.

关 键 词：石英晶体微天平传感器 核酸检测 蛋白质检测 癌细胞检测 微生物检测 

分 类 号：R318[医药卫生—生物医学工程] TP212[医药卫生—基础医学]