超临界流体色谱-质谱接口技术及应用进展  

Research Progress and Application of Interfacing of Supercritical Fluid Chromatography and Mass Spectrometry

作　　者：杨学舸 陈怀义 潘星宇 杨金磊 唐飞[1] 张四纯[2] YANG Xue-Ge;CHEN Huai-Yi;PAN Xing-Yu;YANG Jin-Lei;TANG Fei;ZHANG Si-Chun(Department of Precision Instrument,Tsinghua University,Beijing 100084,China;Department of Chemistry,Tsinghua University,Beijing 100084,China)

机构地区：[1]清华大学精密仪器系,北京100084 [2]清华大学化学系,北京100084

出　　处：《分析化学》2024年第10期1465-1474,共10页Chinese Journal of Analytical Chemistry

基　　金：国家重大科研仪器研制项目(No.20221310054)资助。

摘　　要：在过去的几十年里,超临界流体色谱(Supercritical fluid chromatography,SFC)作为液相色谱(Liquid chromatography,LC)分离技术的补充引起了研究者的极大关注,特别是SFC与质谱(Mass spectrometry,MS)联用,在代谢组学和脂质组学等方面展示了广阔的应用前景。与LC-MS的接口相比,SFC-MS的接口存在一些特殊的问题,需要采用专门设计方案才能解决。本文对SFC-MS接口技术进行了归纳、分类和总结,重点介绍了不同接口设计对检测性能的影响,总结了不同类型接口的适用性,评述了SFC-MS在不同领域的应用进展,并对其发展趋势进行了分析和展望。In the past few decades,supercritical fluid chromatography(SFC)as a supplement to liquid chromatography(LC)separation technology has attracted people′s interest,especially in the combination of SFC and mass spectrometry(MS),which has shown important application prospects in metabolomics,lipidomics,and other fields.Compared to the interface of LC-MS,the interface of SFC-MS presents some unique challenges that require special solutions to be designed.This article categorizes and summarizes the existing interfaces used for SFC-MS,focuses on the impact of different interface designs on detection performance,provides the applicable characteristics of different types of interfaces,and finally briefly introduces the application progress of SFC-MS in different fields.

关 键 词：超临界流体色谱 质谱 接口 评述 

分 类 号：O657.63[理学—分析化学]