血清Actinin-4和NDRG4对早期肺癌患者根治术后复发转移的预测价值  

Predictive value of serum Actinin-4 and NDRG4 for postoperative recurrence and metastasis in early stage lung cancer patients undergoing radical surgery

作　　者：王晓强 孙玉满 郑玄 赵鑫鑫 郑晶晶[1] WANG Xiaoqiang;SUN Yuman;ZHENG Xuan;ZHAO Xinxin;ZHENG Jingjing(Department of Thoracic Surgery;Department of Pathology,Affiliated Hospital of Tangshan Vocational and Technical College,Tangshan,Hebei 063000,China)

机构地区：[1]唐山职业技术学院附属医院胸外科,河北唐山063000 [2]唐山职业技术学院附属医院病理科,河北唐山063000

出　　处：《国际检验医学杂志》2024年第22期2743-2746,共4页International Journal of Laboratory Medicine

基　　金：河北省卫生计生委办公室医学科学研究重点课题(20181313)。

摘　　要：目的探究血清辅肌动蛋白4(Actinin-4)和抑癌基因N-myc下游调节因子4(NDRG4)对早期肺癌患者根治术后复发转移的预测价值。方法选择2020年1月至2022年1月在该院接受早期肺癌根治术治疗的110例患者为研究对象,并根据在1年随访中患者是否出现复发转移情况,分为复发组(62例)和未复发组(48例)。采用酶联免疫吸附试验(ELISA)检测血清Actinin-4、NDRG4水平,Pearson法和Spearman法分析相关性;Logistic回归分析早期肺癌患者根治术后复发转移的影响因素,受试者工作特征(ROC)曲线分析血清Actinin-4、NDRG4水平对早期肺癌患者根治术后复发转移的预测价值。结果与未复发组相比,复发组患者血清Actinin-4水平显著升高,NDRG4水平显著降低,且两组患者淋巴结转移、临床分期比较,差异有统计学意义(P<0.05);Pearson法分析显示,复发组血清Actinin-4、NDRG4水平呈负相关(r=-0.566,P<0.05);Spearman法分析显示,Actinin-4与淋巴结转移、临床分期呈正相关(r=0.429、0.396,P<0.05),NDRG4与淋巴结转移、临床分期呈负相关(r=-0.411、-0.431,P<0.05);Logistic回归分析显示,淋巴结转移、临床分期、Actinin-4、NDRG4水平均可作为影响早期肺癌患者根治术后复发转移的影响因素(P<0.05);ROC曲线分析得出,血清Actinin-4、NDRG4预测早期肺癌患者根治术后复发转移的曲线下面积(AUC)分别为0.857、0.848,联合预测的AUC为0.950,优于二者单独预测(P<0.05)。结论早期肺癌患者根治术后复发转移患者血清Actinin-4水平升高、NDRG4水平降低,二者联合检测可作为预测早期肺癌患者根治术后复发转移的辅助指标。Objective To investigate the predictive value of serum Actinin-4 and N-myc downscream regulated gene 4(NDRG4)for recurrence and metastasis in early stage lung cancer patients.Methods A total of 110 patients who underwent early lung cancer radical surgery in the hospital from January 2020 to January 2022 were collected as the study subjects.They were separated into a recurrence group of 62 patients and a non recurrence group of 48 patients based on whether they experienced recurrence or metastasis during a one-year follow-up.Enzyme-linked immunosorbnent assay(ELISA)method was applied to detect serum Actinin-4 and NDRG4 levels.Pearson and Spearman methods were used for correlation analysis.Logistic regression was applied to analyze the influencing factors of recurrence and metastasis in early stage lung cancer patients after radical surgery.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum Actinin-4 and NDRG4 levels for recurrence and metastasis in early stage lung cancer patients after radical surgery.Results Compared with the non recurrence group,the serum Actinin-4 level in the recurrence group was obviously increased,while the NDRG4 level was obviously reduced,and there was a obvious difference in TNM staging and lymph node metastasis between the two groups(P<0.05).Pearson analysis showed that there was a negative correlation between serum Actinin-4 and NDRG4 levels in the recurrence group(r=-0.566,P<0.05).Spearman analysis showed that Actinin-4 was positively correlated with lymph node metastasis and clinical staging(r=0.429,0.396,P<0.05),while NDRG4 was negatively correlated with lymph node metastasis and clinical staging(r=-0.411,-0.431,P<0.05).Logistic regression analysis showed that lymph node metastasis,clinical staging,Actinin-4,and NDRG4 levels could all be used as influencing factors for postoperative recurrence and metastasis in early stage lung cancer patients after radical surgery(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of se

关 键 词：早期肺癌 复发转移 辅肌动蛋白4 抑癌基因N-myc下游调节因子4 

分 类 号：R734.2[医药卫生—肿瘤]