上皮性卵巢癌患者血清APRIL、Gal-1水平与临床特征和预后的关系  

Relationship between serum APRIL and Gal-1 levels with clinical features and prognosis in patients with epithelial ovarian cancer

作　　者：刘素华 王浩丽 王静 姚俊叶 刘肖 王晓清 高谋林 LIU Suhua;WANG Haoli;WANG Jing;YAO Junye;LIU Xiao;WANG Xiaoqing;GAO Moulin(Department of Obstetrics and Gynecology,Handan Hangang Hospital of Hebei Province,Handan,Hebei 056002,China;Department of Obstetrics and Gynecology,Zhangjiakou Maternal and Child Health Hospital,Zhangjiakou,Hebei 075000,China)

机构地区：[1]河北省邯郸邯钢医院妇产科,河北邯郸056002 [2]河北省张家口市妇幼保健院妇产科,河北张家口075000

出　　处：《国际检验医学杂志》2024年第22期2767-2772,共6页International Journal of Laboratory Medicine

基　　金：河北省2024年度医学科学研究课题计划项目(20240431)。

摘　　要：目的分析上皮性卵巢癌(EOC)患者血清增殖诱导配体(APRIL)、半乳糖凝集素-1(Gal-1)水平与临床特征和预后的关系。方法选取2018年1月至2020年6月在河北省邯郸邯钢医院就诊的EOC患者(n=132)作为癌症组,并根据患者出院后3年生存情况分为生存组(n=56)和死亡组(n=76),同时选取体检健康者(n=68)作为健康组。采用酶联免疫吸附试验检测所有受试者血清APRIL、Gal-1水平;收集所有患者的临床资料,并分析其与血清APRIL、Gal-1水平、预后的关系;采用Kaplan-Meier法分析血清APRIL、Gal-1水平与EOC患者预后的关系;采用Cox回归分析影响EOC患者预后死亡的相关因素;绘制受试者工作特征(ROC)曲线分析血清APRIL、Gal-1预测EOC患者预后的价值。结果癌症组的血清APRIL、Gal-1水平显著高于健康组,差异有统计学意义(P<0.05),且死亡组血清APRIL、Gal-1水平显著高于生存组,差异有统计学意义(P<0.05);临床资料分析显示,血清APRIL、Gal-1水平与EOC患者的年龄无关(P>0.05),与肿瘤位置、肿瘤最大径、国际妇产科联盟(FIGO)分期、分化程度、是否有淋巴结转移、组织学分型及糖类抗原125(CA125)、人附睾蛋白4(HE4)水平有关,且FIGO分期、分化程度、是否有淋巴结转移、组织学分型、CA125、HE4水平也影响患者预后情况(P<0.05);FIGO分期Ⅲ+Ⅳ期、低分化程度、淋巴结转移、浆液性组织学分型、CA125≥200 U/mL、HE4≥200 pmol/L及高表达的APRIL、Gal-1均是EOC患者预后死亡的危险因素(P<0.05);APRIL高表达患者3年生存率(25.37%)显著低于低表达患者(60.00%),Gal-1高表达患者3年生存率(27.94%)显著低于低表达组(57.81%),差异有统计学意义(P<0.05);ROC曲线表明,APRIL、Gal-1联合对预后预测的曲线下面积(AUC)为0.925,明显高于二者单独诊断(Z联合-APRIL=4.061、P<0.001;Z联合-Gal-1=3.424、P<0.001),其灵敏度、特异度分别为86.84%、83.93%。结论血清APRIL、Gal-1水平在EOC患者中显�Objective To analyze the relationship between serum a proliferation inducing ligand(APRIL)and galactin-1(Gal-1)levels with clinical features and prognosis in patients with epithelial ovarian cancer(EOC).Methods EOC patients(n=132)who admitted in Handan Hangang Hospital of Hebei Province from January 2018 to June 2020 were selected as the cancer group,and were grouped into a survival group(n=56)and a death group(n=76)based on their three-year survival after discharge.Meanwhile,healthy individuals(n=68)who underwent physical examination were regarded as the healthy group.Enzyme linked immunosorbent assay was applied to detect serum APRIL and Gal-1 levels in all subjects.Clinical data of all patients were collected and their relationship with serum APRIL,Gal-1 levels and prognosis was analyzed.Kaplan-Meier method was applied to analyze the relationship between serum APRIL and Gal-1 levels and the prognosis of EOC patients.Cox regression was applied to analyze the relevant factors affecting the prognostic death of EOC patients.The prognostic value of serum APRIL in patients with EOC was analyzed by receiver operating characteristic(ROC)curve.Results The serum APRIL and Gal-1 expression levels in the cancer group were greatly higher than those in the healthy group,and the differences were statistically significant(P<0.05).The serum APRIL and Gal-1 levels in the death group were greatly higher than those in the survival group,and the differences were statistically significant(P<0.05).Clinical data analysis showed that serum APRIL and Gal-1 levels were not related to the age of EOC patients(P>0.05),but were related to tumor location,tumor diameter,The International Febderation of Gynecology and Obstetrics(FIGO)staging,differentiation degree,lymph node metastasis,histological classification,and levels of cancer antigen 125(CA125)and human epididymis protein 4(HE4),and FIGO staging,differentiation degree,lymph node metastasis,histological classification,and levels of CA125 and HE4 also significantly affected the prognosis

关 键 词：上皮性卵巢癌 增殖诱导配体 半乳糖凝集素-1 临床特征 预后 

分 类 号：R737.31[医药卫生—肿瘤]