基于数据挖掘技术分析针刺治疗帕金森病便秘的选穴规律  

Acupoint Selection Rules of Acupuncture Treatment for Constipation in Parkinson's Disease Based on Data Mining Techniques

作　　者：吴春媛 时晶[1] 李婷[1] 倪敬年[1] 魏明清[1] WU Chunyuan;SHI Jing;LI Ting;NI Jingnian;WEI Mingqing(Department of Neurology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院脑病科三区,北京市100700

出　　处：《实用心脑肺血管病杂志》2024年第12期104-109,共6页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金资助项目(82204921);解码中医协同攻关项目(BZY-JMZY-2022-002)。

摘　　要：目的基于数据挖掘技术分析针刺治疗帕金森病(PD)便秘的选穴规律。方法计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献服务系统、Web of Science、PubMed、Embase及Cochrane Library中针刺治疗PD便秘的随机对照试验,检索时间为2014-01-01至2024-04-01。统计腧穴使用频次、归经、分布部位及特定穴,对腧穴进行系统聚类分析及关联规则分析。结果最终纳入文献23篇,提取针刺处方23条,涉及腧穴63个,腧穴总使用频次为209次。针刺治疗PD便秘的高频腧穴为天枢穴、上巨虚穴、足三里穴,总使用频次排名前3位的经脉分别是足阳明胃经、足太阳膀胱经、任脉,腧穴主要分布在下肢、上肢、腹部。在针刺治疗PD便秘的63个腧穴中,有33个特定穴,其总使用频次为199次,占腧穴总使用频次的95.2%(199/209),其中总使用频次排名前3位的特定穴依次是五输穴、下合穴、原穴。系统聚类分析结果显示,当冰柱图群集数标度为10、树状图标度为15时,得到3个有效聚类群,分别为“尺泽穴-委中穴-阳池穴-中脘穴-内关穴-曲池穴-阳陵泉穴-合谷穴-太溪穴-四神聪穴-大肠俞穴”“支沟穴-归来穴-足三里穴-气海穴”“天枢穴-上巨虚穴”。关联规则分析结果显示,当最低条件支持度为20%、最小规则置信度为80%时,得到30个组合,其中足三里穴-气海穴+上巨虚穴组合关联性最强。结论针刺治疗PD便秘选穴以足阳明胃经腧穴为主,集中在四肢和腹部,重视特定穴的使用,遵循“远近配穴”原则,重视从脾、胃论治。Objective To explore the acupoint selection rules of acupuncture treatment for constipation in Parkinson's disease(PD)based on data mining technology.Methods Randomized controlled trials of acupuncture treatment for PD constipation were searched by computer from CNKI,Wanfang Data,VIP,Chinese Biomedical Literature Database,Web of Science,PubMed,Embase,and Cochrane Library.The search period was from January 1,2014 to April 1,2024.Use frequency,meridians and distribution sites of acupoints,and specific points were counted,and systematic cluster analysis and association rule analysis were performed on the acupoints.Results A total of 23 articles were included;23 acupuncture prescriptions were extracted,involving 63 acupoints,and the total frequency of use was 209.High-frequency acupoints of acpuncture treatment for PD constipation were Tianshu,Shangjuxu and Zusanli,and the top 3 meridians in terms of use frequency were the stomach channel of foot-Yangming,the bladder meridian of foot-Taiyang,and the Ren channel,and the acupoints were mainly distributed in the lower limbs,the upper limbs,and the abdomen.Among the 63 acupoints used in acupuncture treatment for PD constipation,there were 33 specific points with a total use frequency of 199,accounting for 95.2%(199/209)of the total frequency of use of the acupoints,of which the top 3 specific points in terms of use frequency were Wushu,Xiahe,and Yuan.Systematic clustering analysis showed that three valid clusters were obtained when the cluster number scale of the icicle diagram was 10 and the dendrogram scale was 15,which were"Chize-Weizhong-Yangchi-Zhongkou-Neiguan-Quchi-Yanglingquan-Hegu-Taixi-Sishencong-Dachangyu""Zhigou-Guilai-Zusanli-Qihai"and"Tianshu-Shangjuxu".Association rule analysis showed that 30 combinations were obtained when the minimum conditional support was 20% and the minimum rule confidence level was 80%,among which the combination of Zusanli-Qihai+Shangjuxu had the strongest association.Conclusion Acupoint of acupuncture treatment for PD constipation

关 键 词：帕金森病 便秘 针刺疗法 穴位 数据挖掘 

分 类 号：R742.5[医药卫生—神经病学与精神病学]