血常规及生化指标在帕金森病诊断和分期中的临床意义  

Clinical Significance of Blood Routine and Biochemical Indexes in the Diagnosis and Staging of Parkinson's Disease

作　　者：童洋萍 李波 胡珏 李芳毅[1] 王振 陈素芬[1] TONG Yangping;LI Bo;HU Jue;LI Fangyi;WANG Zhen;CHEN Sufen(Department of Neurology,Changsha Central Hospital Affiliated to University of South China,Changsha 410004,Hunan,China;Department of Neurology,Fuyang Hospital of Anhui Medical University,Fuyang 236000,Anhui,China)

机构地区：[1]南华大学附属长沙中心医院神经内科,湖南长沙410004 [2]安徽医科大学附属阜阳医院神经内科,安徽阜阳236000

出　　处：《医学信息》2024年第21期54-60,共7页Journal of Medical Information

基　　金：湖南省卫生健康委2020年度科研立项课题(编号:20201928);长沙市2020年度指导性科技计划项目(编号:kzd2001077)。

摘　　要：目的分析血常规和生化指标在帕金森病(PD)中的临床意义。方法将2020年1月-2021年9月在南华大学附属长沙中心医院神经内科住院治疗的95例PD患者设为PD组,根据HY分期系统将PD组分为早期(1~2级,n=46)和中晚期(3~5级,n=49),另选择健康受试者76名作为对照组,收集两组血常规和生化指标,采用单因素及多因素分析PD的影响因素,并采用ROC曲线分析各指标在PD诊断中的价值,另分析不同HY分期患者血常规和生化指标。结果PD组与对照组TG、LDL、TC、NC、LC、MC、H/L ratio、MHR、NHR、LHR比较,差异有统计学意义(P<0.05),而两组HDL、白蛋白、尿酸、NMR、LMR、NLR比较,差异无统计学意义(P>0.05)。单因素Logistic回归分析显示,TG、LDL、TC、H/L ratio、MHR、NHR、LHR与PD有关,且多因素Logistic回归分析显示,TC(OR=0.666,P=0.020)、NHR(OR=0.760,P=0.015)和LHR(OR=0.442,P=0.006)为PD的独立影响因素,皆为保护因素;Logistic二元回归模型发现,联合TC、NHR和LHR三者一起为检验变量,以整体PD诊断的有无为状态变量,ROC曲线下面积AUC为0.706(95%CI:0.627~0.784),模型敏感度为71.60%,特异度为64.50%;中晚期PD组和早期PD组白蛋白比较,差异有统计学意义(P<0.05),而两组其余指标比较,差异无统计学意义(P>0.05)。结论血常规及生化指标在PD的发病、分期及诊断中起着重要作用。Objective To analyze the clinical significance of blood routine and biochemical indexes in Parkinson's disease(PD).Methods A total of 95 PD patients who were hospitalized in the Department of Neurology,Changsha Central Hospital Affiliated to University of South China from January 2020 to September 2021 were set as the PD group.According to the HY classification system,the PD group was divided into early stage(grade 1-2,n=46)and middle-late stage(grade 3-5,n=49).Another 76 healthy subjects were selected as the control group.The blood routine and biochemical indexes of the two groups were collected.The influencing factors of PD were analyzed by univariate and multivariate analysis.The ROC curve was used to analyze the value of each index in the diagnosis of PD,and the blood routine and biochemical indexes of patients with different HY stages were analyzed.Results There were significant differences in TG,LDL,TC,H/L ratio,MHR,NHR and LHR between PD group and healthy group(P<0.05),while there was no significant difference in HDL,albumin,uric acid,NMR,LMR and NLR between the two groups(P>0.05).Univariate logistic regression analysis showed that TG,LDL,TC,NC,LC,MC,H/L ratio,MHR,NHR and LHR were related to PD,and multivariate logistic regression analysis showed that TC(OR=0.666,P=0.020),NHR(OR=0.760,P=0.015)and LHR(OR=0.442,P=0.006)were independent influencing factors of PD,all of which were protective factors.The logistic binary regression model found that the combination of TC,NHR and LHR was the test variable,and the presence or absence of the overall PD diagnosis was the state variable.The area under the ROC curve was 0.706(95%CI:0.627-0.784),the model sensitivity was 71.60%,and the specificity was 64.50%.There was a statistically significant difference in albumin between the advanced PD group and the early PD group(P<0.05),but there was no significant difference in the other indexes between the two groups(P>0.05).Conclusion Blood routine and biochemical indexes play an important role in the pathogenesis,staging and

关 键 词：帕金森病 生化指标 炎症指标 血脂 白蛋白 

分 类 号：R742.5[医药卫生—神经病学与精神病学]