重组人干扰素α2a栓联合康妇凝胶治疗对高危型HPV感染患者免疫功能及转阴率的影响  

Effect of Recombinant Human Interferon α2a Suppository Combined with Kangfu Gel on Immune Function and Negative Conversion Rate in Patients with High-risk HPV Infection

作　　者：聂俊玲 江小华 刘庆春 邓娟华 NIE Junling;JIANG Xiaohua;LIU Qingchun;DENG Juanhua(Department of Obstetrics and Gynecology,Xiajiang County Maternal and Child Health FamilyPlanning Service Center,Xiajiang 331400,Jiangxi,China)

机构地区：[1]峡江县妇幼保健计划生育服务中心妇产科,江西峡江331400

出　　处：《医学信息》2024年第21期70-73,共4页Journal of Medical Information

基　　金：江西省吉安市科技计划项目(编号:20233-043722)。

摘　　要：目的研究重组人干扰素α2a(rhIFN-α2a)栓联合康妇凝胶治疗对提高高危型人乳头瘤病毒(HPV)感染患者免疫功能及转阴率的意义。方法以2021年1月-2023年3月峡江县妇幼保健计划生育服务中心收治的60例高危型HPV感染患者为研究对象,行随机数字表法分为对照组(30例)与观察组(30例)。对照组采用rhIFN-α2a栓治疗,观察组在对照组基础上联合康妇凝胶治疗,比较两组临床疗效、免疫功能(CD8^(+)、CD4^(+)、CD4^(+)/CD8^(+))、炎症因子[转化生长因子-β_(1)(TGF-β_(1))、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、HPV转阴率与HPV感染复发率。结果观察组治疗总有效率为96.67%,高于对照组的80.00%(P<0.05);两组治疗后CD4^(+)、CD4^(+)/CD8^(+)高于治疗前,且观察组治疗后CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05);两组治疗后TGF-β_(1)、IL-6、TNF-α水平低于治疗前,且观察组治疗后TGF-β_(1)、IL-6、TNF-α水平低于对照组(P<0.05);观察组HPV转阴率高于对照组,且HPV感染复发率低于对照组(P<0.05)。结论rhIFN-α2a栓联合康妇凝胶在高危型HPV感染治疗中具有良好疗效,可增强患者免疫功能,减轻机体炎症反应,提高其HPV转阴率,降低复发风险。Objective To study the significance of recombinant human interferon α2a(rhIFN-α2a)suppository combined with Kangfu gel in improving the immune function and negative conversion rate of patients with high-risk human papillomavirus(HPV)infection.Methods A total of 60 patients with high-risk HPV infection admitted to Xiajiang County Maternal and Child Health Care and Family Planning Service Center from January 2021 to March 2023 were enrolled in the study.They were divided into control group(30 patients)and observation group(30 patients)by random number table method.The control group was treated with rhIFN-α2 a suppository,and the observation group was treated with Kangfu gel on the basis of the control group.The clinical efficacy,immune function(CD8^(+),CD4^(+),CD4^(+)/CD8^(+)),inflammatory factors[transforming growth factor-β_(1)(TGF-β_(1)),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],HPV negative conversion rate and HPV infection recurrence rate were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than 80.00%in the control group(P<0.05).After treatment,CD4^(+)and CD4^(+)/CD8^(+)in the two groups were higher than those before treatment,and CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of TGF-β_(1),IL-6 and TNF-α in the two groups were lower than those before treatment,and the levels of TGF-β_(1),IL-6 and TNF-α in the observation group were lower than those in the control group(P<0.05).The negative conversion rate of HPV in the observation group was higher than that in the control group,and the recurrence rate of HPV infection was lower than that in the control group(P<0.05).Conclusion rhIFN-α2a suppository combined with Kangfu gel has a good effect in the treatment of high-risk HPV infection,which can enhance the immune function of patients,reduce the body's inflammatory response,improve the HPV negative rate and reduce the risk of

关 键 词：高危型HPV感染 重组人干扰素α2a栓 康妇凝胶 免疫功能 

分 类 号：R737.33[医药卫生—肿瘤]