盐酸普拉克索联合右佐匹克隆治疗帕金森病合并睡眠障碍的临床效果  

Clinical Effect of Pramipexole Dihydrochloride Combined with Eszopiclone in the Treatment of Parkinson's Disease with Sleep Disorder

作　　者：肖静 何魏 肖小富 XIAO Jing;HE Wei;XIAO Xiaofu(Department of Neurology,Xinfeng County People's Hospital,Xinfeng 341600,Jiangxi,China;ECG Room of Xinfeng County Hospital of Traditional Chinese Medicine,Xinfeng 341600,Jiangxi,China;Department of Internal Medicine,Xinfeng County Xiaohe Town Central Hospital,Xinfeng 341600,Jiangxi,China)

机构地区：[1]信丰县人民医院神经内科,江西信丰341600 [2]信丰县中医院心电图室,江西信丰341600 [3]信丰县小河镇中心卫生院内科,江西信丰341600

出　　处：《医学信息》2024年第21期119-122,共4页Journal of Medical Information

基　　金：赣州市指导性科技计划项目(编号:GZ2023ZSF658)。

摘　　要：目的研究盐酸普拉克索联合右佐匹克隆治疗帕金森病(PD)合并睡眠障碍的临床效果。方法以2022年1月-2023年8月信丰县人民医院神经内科收治的62例PD合并睡眠障碍患者为研究对象,经随机数字表法分为对照组和观察组,各31例。对照组采用盐酸普拉克索治疗,观察组在其基础上联合右佐匹克隆治疗,比较两组临床疗效、帕金森病评分量表(UPDRS)评分、匹兹堡睡眠质量指数量表(PSQI)评分及疲劳量表(FS-14)评分。结果观察组治疗总有效率(93.55%)高于对照组(74.19%)(P<0.05)。两组治疗后UPDRS评分(NEDL、ADL、ME)均低于治疗前,且观察组UPDRS评分(NEDL、ADL、ME)低于对照组(P<0.05)。两组治疗后PSQI评分低于治疗前,且观察组治疗后PSQI评分低于对照组(P<0.05)。两组治疗后FS-14评分(躯体疲劳、脑力疲劳)均低于治疗前,且观察组治疗后FS-14评分(躯体疲劳、脑力疲劳)低于对照组(P<0.05)。结论盐酸普拉克索联合右佐匹克隆在PD伴睡眠障碍治疗中具有确切疗效,其治疗效果好,可减轻患者PD症状,改善其睡眠质量,缓解其疲劳状态,值得应用。Objective To study the clinical effect of pramipexole dihydrochloride combined with eszopiclone in the treatment of Parkinson's disease(PD)with sleep disorders.Methods From January 2022 to August 2023,62 patients with PD complicated with sleep disorder admitted to the Department of Neurology,Xinfeng County People's Hospital were selected as the research objects.They were divided into control group and observation group by random number table method,with 31 patients in each group.The control group was treated with pramipexole dihydrochloride,and the observation group was treated with dexzopiclone on the basis of the control group.The clinical efficacy,the Unified Parkinson's Disease Rating Scale(UPDRS)score,Pittsburgh Sleep Quality Index Scale(PSQI)score and Fatigue Scale(FS-14)score were compared between the two groups.Results The total effective rate of treatment in the observation group(93.55%)was higher than that in the control group(74.19%)(P<0.05).After treatment,the UPDRS scores(NEDL,ADL,ME)of the two groups were lower than those before treatment,and the UPDRS scores(NEDL,ADL,ME)of the observation group were lower than those of the control group(P<0.05).The PSQI score of the two groups after treatment was lower than that before treatment,and the PSQI score of the observation group after treatment was lower than that of the control group(P<0.05).The FS-14 scores(physical fatigue,mental fatigue)of the two groups after treatment were lower than those before treatment,and the FS-14 scores(physical fatigue,mental fatigue)of the observation group after treatment were lower than those of the control group(P<0.05).Conclusion Pramipexoledihydrochloride combined with dexzopiclone has a definite curative effect in the treatment of PD with sleep disorders.It has a good therapeutic effect,which can reduce the symptoms of PD,improve the quality of sleep,relieve the fatigue state,and is worthy of application.

关 键 词：帕金森病 睡眠障碍 盐酸普拉克索 右佐匹克隆 睡眠质量 疲劳状态 

分 类 号：R742[医药卫生—神经病学与精神病学]